Seroatlas · Human Serome Atlas

CFAP97

Cilia- and flagella-associated protein 97

Also known as: CFA97_HUMAN, DKFZp434F1728, hmw, KIAA1430

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2B7
Gene: CFAP97
Ensembl: ENSG00000164323
Chromosome: 4
Canonical length: 532 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Primary cilium,Cytosol

OverviewNCBI Gene

No narrative summary is available for CFAP97 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

532 residues, UniProt reviewed canonical sequence.

>Q9P2B7|CFAP97
     1  MDQFGDILEG EVDHSFFDSD FEEGKKCETN SVFDKQNDDP KERIDKDTKN VNSNTGMQTT
    61  ENYLTEKGNE RNVKFPPEHP VENDVTQTVS SFSLPASSRS KKLCDVTTGL KIHVSIPNRI
   121  PKIVKEGEDD YYTDGEESSD DGKKYHVKSK SAKPSTNVKK SIRKKYCKVS SSSSSSLSSS
   181  SSGSGTDCLD AGSDSHLSDS SPSSKSSKKH VSGITLLSPK HKYKSGIKST ETQPSSTTPK
   241  CGHYPEESED TVTDVSPLST PDISPLQSFE LGIANDQKVK IKKQENVSQE IYEDVEDLKN
   301  NSKYLKAAKK GKEKHEPDVS SKSSSVLDSS LDHRHKQKVL HDTMDLNHLL KAFLQLDKKG
   361  PQKHHFDQPS VAPGKNYSFT REEVRQIDRE NQRLLKELSR QAEKPGSKST IPRSADHPPK
   421  LYHSALNRQK EQQRIERENL ALLKRLEAVK PTVGMKRSEQ LMDYHRNMGY LNSSPLSRRA
   481  RSTLGQYSPL RASRTSSATS GLSCRSERSA VDPSSGHPRR RPKPPNVRTA WL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP97 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

testis: 35 nTPM
thyroid gland: 25 nTPM
blood vessel: 21 nTPM
breast: 19 nTPM
ovary: 19 nTPM
parathyroid gland: 19 nTPM

Single-cell type

late primary spermatocytes: 462 nCPM
early spermatids: 244 nCPM
late spermatids: 218 nCPM
differentiating spermatogonia: 156 nCPM
alveolar cells type 1: 130 nCPM
fallopian tube ciliated cells: 101 nCPM

Immune cell

MAIT T-cell: 20 nTPM
memory B-cell: 19 nTPM
naive B-cell: 18 nTPM
plasmacytoid DC: 18 nTPM
gdT-cell: 17 nTPM
memory CD4 T-cell: 17 nTPM

Brain region

white matter: 31 nTPM
choroid plexus: 30 nTPM
cerebellum: 28 nTPM
medulla oblongata: 27 nTPM
cerebral cortex: 26 nTPM
hypothalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Hemingway/CFA97
Hemingway/CFA97
Cilia- and flagella-associated protein 97

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP97 as an antibody target. Whether an autoantibody or antibody against CFAP97 could matter depends on whether native CFAP97 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP97 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP97 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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