Seroatlas · Human Serome Atlas

CFAP96

Cilia-and flagella-associated protein 96

Also known as: C4orf47, CFA96_HUMAN, LOC441054

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A7E2U8
Gene: CFAP96
Ensembl: ENSG00000205129
Chromosome: 4
Canonical length: 309 aa
Protein class: Predicted intracellular proteins
Subcellular location: Principal piece,End piece

OverviewNCBI Gene

Located in 9+0 non-motile cilium; centrosome; and cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>A7E2U8|CFAP96
     1  MPAEGGKTDM ERIGLFSEME YITVGDKYVS QFNRPFNEAA SKNKQMLPGG SKEMSDLQAG
    61  YFDPHFVRIF EGEGYINLNQ VRRRDMVEAA KKNLGKAFLP SNGEKKPCGL GSYYGTIGGP
   121  VPFFSAQSKP REKYKAPGKN LYTNPGKKGT GYGYANITIG KQFSHSADFY DAAKLKYKKA
   181  NEEHHRLLKG APFKLNLHPR DYFDANPYFS EESLPPIKKE EKKKTISNTF KPSSPGKKPG
   241  GMKAGTFDPY PSHSADPYVA KLANISGKDD KIFHPPSGPK SRPVESIMTL NVRRALNSKN
   301  YKTSSVPSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP96 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 30 nTPM
retina: 13 nTPM
fallopian tube: 11 nTPM
testis: 11 nTPM
thyroid gland: 3.9 nTPM
basal ganglia: 3.5 nTPM

Single-cell type

ependymal cells: 546 nCPM
epididymal efferent duct ciliated cells: 526 nCPM
respiratory ciliated cells: 512 nCPM
fallopian tube ciliated cells: 418 nCPM
choroid plexus epithelial cells: 310 nCPM
late primary spermatocytes: 261 nCPM

Immune cell

neutrophil: 1 nTPM
NK-cell: 0.3 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

choroid plexus: 48 nTPM
midbrain: 17 nTPM
medulla oblongata: 14 nTPM
spinal cord: 14 nTPM
basal ganglia: 8.4 nTPM
pons: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cilia-and flagella-associated protein 96
Cilia-and flagella-associated protein 96

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP96 as an antibody target. Whether an autoantibody or antibody against CFAP96 could matter depends on whether native CFAP96 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP96 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP96 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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