Seroatlas · Human Serome Atlas

CFAP92

Uncharacterized protein CFAP92

Also known as: CFA92_HUMAN, FAP92, FLJ43738, KIAA1257

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULG3
Gene: CFAP92
Ensembl: ENSG00000114656
Chromosome: 3
Canonical length: 409 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CFAP92 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>Q9ULG3|CFAP92
     1  MSLHAWEWEE DPASIEPISS ITSFYQSTSE CDVEEHLKAK ARAQESDSDR PCSSIESSSE
    61  PASTFSSDVP HVVPCKFTIS LAFPVNMGQK GKYASLIEKY KKHPKTDSSV TKMRRFYHIE
   121  YFLLPDDEEP KKVDILLFPM VAKVFLESGV KTVKPWHEGD KAWVSWEQTF NITVTKELLK
   181  KINFHKITLR LWNTKDKMSR KVRYYRLKTA GFTDDVGAFH KSEVRHLVLN QRKLSEQGIE
   241  NTNIVREESN QEHPPGKQEK TEKHPKSLQG SHQAEPETSS KNSEEYEKSL KMDDSSTIQW
   301  SVSRTPTISL AGASMMEIKE LIESESLSSL TNILDRQRSQ IKGKDSEGRR KIQRRHKKPL
   361  AEEEADPTLT GPRKQSAFSI QLAVMPLLAG THCLPCSQQL LLVLWPERP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP92 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
choroid plexus: 4.3 nTPM
pituitary gland: 4.1 nTPM
skin: 4.1 nTPM
thymus: 3.8 nTPM
fallopian tube: 3.1 nTPM

Single-cell type

late spermatids: 321 nCPM
early spermatids: 209 nCPM
late primary spermatocytes: 205 nCPM
ependymal cells: 148 nCPM
epicardial cells: 146 nCPM
respiratory ciliated cells: 90 nCPM

Immune cell

neutrophil: 34 nTPM
eosinophil: 2.9 nTPM
basophil: 0.8 nTPM
classical monocyte: 0.7 nTPM
naive CD8 T-cell: 0.5 nTPM
memory B-cell: 0.4 nTPM

Brain region

midbrain: 21 nTPM
choroid plexus: 20 nTPM
cerebellum: 19 nTPM
hippocampal formation: 18 nTPM
medulla oblongata: 18 nTPM
hypothalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Domain of unknown function DUF4550
Domain of unknown function (DUF4550)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP92 as an antibody target. Whether an autoantibody or antibody against CFAP92 could matter depends on whether native CFAP92 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP92 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP92 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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