Seroatlas · Human Serome Atlas

CFAP90

Cilia- and flagella-associated protein 90

Also known as: C5orf49, CFA90_HUMAN, LOC134121

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4QMS7
Gene: CFAP90
Ensembl: ENSG00000215217
Chromosome: 5
Canonical length: 147 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axoneme and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>A4QMS7|CFAP90
     1  MEDDEEETTA STLRGKPRPP PVSAQSAFSY IPPRRLDPKE HSYYYRPART GIISLYDCIF
    61  KRRLDYDQKL HRDDREHAKS LGLHVNEEEQ ERPVGVLTSS VYGKRINQPI EPLNRDFGRA
   121  NHVQADFYRK NDIPSLKEPG FGHIAPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP90 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 71 nTPM
choroid plexus: 70 nTPM
testis: 37 nTPM
hypothalamus: 21 nTPM
hippocampal formation: 18 nTPM
amygdala: 16 nTPM

Single-cell type

fallopian tube ciliated cells: 938 nCPM
early spermatids: 798 nCPM
respiratory ciliated cells: 771 nCPM
late spermatids: 527 nCPM
epididymal efferent duct ciliated cells: 515 nCPM
late primary spermatocytes: 471 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 44 nTPM
choroid plexus: 39 nTPM
medulla oblongata: 29 nTPM
hypothalamus: 24 nTPM
spinal cord: 22 nTPM
white matter: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0.01
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cilia and flagella associated protein 90
Cilia and flagella associated protein 90

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP90 as an antibody target. Whether an autoantibody or antibody against CFAP90 could matter depends on whether native CFAP90 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP90 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP90 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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