Seroatlas · Human Serome Atlas

CFAP77

Cilia- and flagella-associated protein 77

Also known as: C9orf171, CFA77_HUMAN, FLJ46082

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZQR2
Gene: CFAP77
Ensembl: ENSG00000188523
Chromosome: 9
Canonical length: 320 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q6ZQR2|CFAP77
     1  MPEARSSGPD LTRWRKQQQP VRRTVSQVCP PPRRPLTVAD IRSGMENERL GVVRDSMFQN
    61  PLIVKAAGPA SVGTSYSVYD SSAVQKVIPS LAGHHIKGGP QAELGKPRER SYSLPGINFN
   121  YGLYIRGLDG GVPEAIGRWN VFKQQPTCPH ELTRNYIAMN RGAVKAGLVT ARENLLYRQL
   181  NDIRISDQDD RRMKKEPPPL PPNMTFGIRA RPSTPFFDLL QHRYLQLWVQ EQKATQKAIK
   241  LEKKQKVVLG KLYETRSSQL RKYKPPVKLD TLWHMPHFQK VGRHLDTFPT EADRQRALKA
   301  HREECAVRQG TLRMGNYTHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP77 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 28 nTPM
choroid plexus: 22 nTPM
testis: 18 nTPM
retina: 3.4 nTPM
hippocampal formation: 2.4 nTPM
hypothalamus: 2.3 nTPM

Single-cell type

respiratory ciliated cells: 351 nCPM
fallopian tube ciliated cells: 222 nCPM
ependymal cells: 211 nCPM
endometrial ciliated cells: 203 nCPM
oocytes: 198 nCPM
late primary spermatocytes: 156 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 24 nTPM
midbrain: 13 nTPM
medulla oblongata: 9.1 nTPM
spinal cord: 6.7 nTPM
white matter: 4.4 nTPM
cerebellum: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cilia- and flagella-associated protein 77
Cilia- and flagella-associated protein 77

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP77 as an antibody target. Whether an autoantibody or antibody against CFAP77 could matter depends on whether native CFAP77 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP77 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP77 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...