Seroatlas · Human Serome Atlas

CFAP73

Cilia- and flagella-associated protein 73

Also known as: CCDC42B, CFA73_HUMAN, MIA2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFT4
Gene: CFAP73
Ensembl: ENSG00000186710
Chromosome: 12
Canonical length: 308 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

Predicted to enable dynein complex binding activity. Predicted to be involved in cilium movement and inner dynein arm assembly. Predicted to be located in axonemal doublet microtubule and motile cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>A6NFT4|CFAP73
     1  MAVPWEEYFR LALQEKLSTK LPEQAEDHVP PVLRLLEKRQ ELVDADQALQ AQKEVFRTKT
    61  AALKQRWEQL EQKERELKGS FIRFDKFLQD SEARRNRALR RAAEERHQAG RREVEALRLW
   121  TQLQELRREH ARLQRRLKRL EPCARLLEQA LELLPGFQEV PELVARFDGL AETQAALRLR
   181  EREQLAELEA ARARLQQLRD AWPDEVLAQG QRRAQLQERL EAARERTLQW ESKWIQIQNT
   241  AAEKTLLLGR SRMAVLNLFQ LVCQHQGQPP TLDIEDTEGQ LEHVKLFMQD LSAMLAGLGQ
   301  AEPAAPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP73 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 34 nTPM
choroid plexus: 30 nTPM
hippocampal formation: 9.4 nTPM
hypothalamus: 9.4 nTPM
basal ganglia: 8 nTPM
lung: 6.9 nTPM

Single-cell type

respiratory ciliated cells: 556 nCPM
ependymal cells: 503 nCPM
fallopian tube ciliated cells: 477 nCPM
epididymal efferent duct ciliated cells: 370 nCPM
endometrial ciliated cells: 208 nCPM
choroid plexus epithelial cells: 68 nCPM

Immune cell

naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 58 nTPM
midbrain: 45 nTPM
medulla oblongata: 39 nTPM
spinal cord: 31 nTPM
pons: 17 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

dynein complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP73 as an antibody target. Whether an autoantibody or antibody against CFAP73 could matter depends on whether native CFAP73 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP73 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP73 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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