Seroatlas · Human Serome Atlas

CFAP68

Cilia- and flagella-associated protein 68

Also known as: C11orf1, CFA68_HUMAN, FLJ23499

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H5F2
Gene
CFAP68
Ensembl
ENSG00000137720
Chromosome
11
Canonical length
150 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axoneme and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>Q9H5F2|CFAP68
     1  MAASQCLCCS KFLFQRQNLA CFLTNPHCGS LVNADGHGEV WTDWNNMSKF FQYGWRCTTN
    61  ENTYSNRTLM GNWNQERYDL RNIVQPKPLP SQFGHYFETT YDTSYNNKMP LSTHRFKREP
   121  HWFPGHQPEL DPPRYKCTEK STYMNSYSKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 65 nTPM
  • epididymis: 61 nTPM
  • testis: 57 nTPM
  • basal ganglia: 54 nTPM
  • liver: 51 nTPM
  • breast: 46 nTPM

Single-cell type

  • late spermatids: 1,840 nCPM
  • early spermatids: 456 nCPM
  • late primary spermatocytes: 130 nCPM
  • epididymal principal cells: 123 nCPM
  • epididymal efferent duct absorptive cells: 89 nCPM
  • breast lactating cells: 79 nCPM

Immune cell

  • naive CD4 T-cell: 35 nTPM
  • plasmacytoid DC: 33 nTPM
  • naive CD8 T-cell: 27 nTPM
  • memory B-cell: 26 nTPM
  • MAIT T-cell: 25 nTPM
  • memory CD4 T-cell: 22 nTPM

Brain region

  • basal ganglia: 22 nTPM
  • hypothalamus: 20 nTPM
  • midbrain: 18 nTPM
  • pons: 17 nTPM
  • white matter: 17 nTPM
  • cerebellum: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP68 as an antibody target. Whether an autoantibody or antibody against CFAP68 could matter depends on whether native CFAP68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP68 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFAP68. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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