Seroatlas · Human Serome Atlas

CFAP58

Cilia- and flagella-associated protein 58

Also known as: bA554P13.1, C10orf80, CCDC147, CFA58_HUMAN, FLJ35908

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T655
Gene
CFAP58
Ensembl
ENSG00000120051
Chromosome
10
Canonical length
872 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Calyx,Principal piece

OverviewNCBI Gene

Involved in protein localization to motile cilium; sperm axoneme assembly; and sperm mitochondrial sheath assembly. Located in sperm midpiece. Implicated in spermatogenic failure 49. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

872 residues, UniProt reviewed canonical sequence.

>Q5T655|CFAP58
     1  MAEEKGGKQV LEESAFEEME RDFQGVLHEL SGDKSLEKFR IEYERLHAVM KKSYDNEKRL
    61  MAKCRELNAE IVVNSAKVAT ALKLSQDDQT TIASLKKEIE KAWKMVDSAY DKEQKAKETI
   121  LALKEEIVNL TKLVEQGSGL SMDQHSNIRD LLRFKEEVTK ERDQLLSEVV KLRESLAQTT
   181  EQQQETERSK EEAEHAISQF QQEIQQRQNE ASREFRKKEK LEKELKQIQA DMDSRQTEIK
   241  ALQQYVQKSK EELQKLEQQL KEQKILNERA AKELEQFQMR NAKLQQENEQ HSLVCEQLSQ
   301  ENQQKALELK AKEEEVHQMR LDIGKLNKIR EQIHKKLHHT EDQKAEVEQH KETLKNQIVG
   361  LEREVEASKK QAELDRKAMD ELLRERDILN KNMLKAVNAT QKQTDLVKLH EQAKRNLEGE
   421  IQNYKDEAQK QRKIIFHLEK ERDRYINQAS DLTQKVLMNM EDIKVRETQI FDYRKKIAES
   481  EIKLKQQQNL YEAVRSDRNL YSKNLVEAQD EITDMKRKLK IMIHQVDELK EDISAKESAL
   541  VKLHLEQQRI EKEKETLKAE LQKLRQQALE TKHFIEKQEA EERKLLRIIA EADGERLRQK
   601  KELDQVISER DILGSQLVRR NDELALLYEK IKIQQSVLNK GESQYNQRLE DMRILRLEIK
   661  KLRREKGILA RSMANVEELR QEFFHMQREL LKERTRCRAL EEELENPLNV HRWRKLEASD
   721  PNAYELIQKI HTLQKRLISK TEEVVEKELL LQEKEKLYME LKHVLARQPG PEAAEQLKLY
   781  RRTLHDKKQQ LKVLSSELNM YEVQSKEYKY EVEKLTNELQ NLKKKYLAQK RKEQLQKNKD
   841  TAPMDNTFLM VKPNGPGFTG GGFPLRSTKM TF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • fallopian tube: 7.9 nTPM
  • choroid plexus: 3.1 nTPM
  • heart muscle: 2.5 nTPM
  • cervix: 2 nTPM
  • endometrium: 1.7 nTPM

Single-cell type

  • ependymal cells: 207 nCPM
  • respiratory ciliated cells: 171 nCPM
  • fallopian tube ciliated cells: 132 nCPM
  • late primary spermatocytes: 108 nCPM
  • late spermatids: 78 nCPM
  • epididymal efferent duct ciliated cells: 61 nCPM

Immune cell

  • neutrophil: 2.1 nTPM
  • eosinophil: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 8 nTPM
  • medulla oblongata: 6.7 nTPM
  • choroid plexus: 5.2 nTPM
  • spinal cord: 4.4 nTPM
  • pons: 3.1 nTPM
  • basal ganglia: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFAP58.

Disease | AllUniProt

Conditions CFAP58 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 157 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 49

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cilia- and flagella-associated protein 58, central coiled coil
  • CFAP58 central coiled coil

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP58 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP58 as an antibody target. Whether an autoantibody or antibody against CFAP58 could matter depends on whether native CFAP58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFAP58. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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