Seroatlas · Human Serome Atlas

CFAP46

Cilia- and flagella-associated protein 46

Also known as: bA288G11.4, bA288G11.5, bB137A17.2, bB137A17.3, C10orf123, C10orf124, C10orf92, C10orf93, CFA46_HUMAN, DKFZp434A1721, FLJ25954, TTC40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYW2
Gene: CFAP46
Ensembl: ENSG00000171811
Chromosome: 10
Canonical length: 2715 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mid piece,Principal piece,Annulus

OverviewNCBI Gene

Predicted to be involved in axoneme assembly. Predicted to be located in axoneme. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2715 residues, UniProt reviewed canonical sequence.

>Q8IYW2|CFAP46
     1  MDLVITQELA RAESQQDAAS LKKAYELIKS ANLGKSEFDP SESFSPDLFV LCAEQALKMR
    61  QPEVSEDCIQ MYFKVKAPIT QFLGRAHLCR AQMCAPKSAE NLEEFENCVT EYMKAINFAK
   121  GEPRYYFLVY NASVLYWQMV RPFLKPGYRH HLIPSLSQII NVLSQTEEED KEWRAELMLE
   181  LLECYLQAGR KEEAARFCST AAPFIKSHVP QKYRQIFSVM VRHELMDELQ LKEEKKNSIS
   241  LSVTFYINML KAKAEQNDLP GDISVILRKA YRHLGHYNHQ RFPSISEEKM LLLFELARFS
   301  LTLKCMEISS ACLSDLKKME SKDPGKLIEM ECLECESEAL RLESKMKVYN RAAVEAQLDI
   361  IQRLDVALQR AVRLGDPRVI HVVCATQWNT CLPLLQHNLR HHLRKPLAGV ADVLEKLDSL
   421  MTLLRCQVHM EMAQIEEDED RLEPATEHLR KAARLDSLGL YRDRIQMAST RLRLCTTLYQ
   481  APERAEDKAI MAVEQAKKAT PKDSVRKKRA LLVNAGLALA PDAFQIVLDS ENEAKVSTGK
   541  NRGRFTYLCA KAWHHTVSVD KAAGHLRRLG NENDKERIQI WAELAKVARK QGVWDVCRTA
   601  SRFCLLYDNV KVKKLRLRRG KKKRGRDGSV QDTWSQPEVV LQRQVCPDLL RKFAEVGFIH
   661  AEATVHLLRS EGVELNDRAI PPEDLSQHPA GYVPEPPEVN AEWITYRTWI ESLSRCAMNN
   721  WLRSAEIGQE IQEAWIVQNA VVYVLNHNHH LILAGRQKEL VDALYHLLSI VKATGHSGDP
   781  VMLVTLCNTL ARGLIISWIP VQAAEKSRKF MRPNAFHSPL DAGATSEIKT AVEVCEFALN
   841  LTNGSAPEET VPTGTRQQLI ATWVKAKQLL QQQIGPRLGT EEQGTNEDVS SVTRVLVALE
   901  MYSCNGLGLM DFTVPSLAQL VKMASECNWS DPLVELQTLT RLTHFAHAAR DHETTMACAH
   961  RALEMGIKYL KKFGPEESRL VAEMLCTATA IQGRSIMENL KGRKQLRLVA AKAFTESARF
  1021  GGIAGSSALV MLAARHYWNA WLPLLSSAVY RKKAKGALKR LIGIINKTEA RKQEKGKTLL
  1081  LHQWPTADFQ GGGTTEGYFL PGAEDDLALR AALYGLLFHS HADQDDWEGG LKVLDEAVQV
  1141  LPRTAHRLLI FKHMVIVKAK LGQNFSMEIQ KFKAESEDYL ARMWHRLALN SPSVSGELAC
  1201  YNNAIQALQK PEMEWQKVEY LMEFGQWLHH RHFPLEDVVF HLRWAVEILL AMKPPGDVPE
  1261  PQPTPDGEYV AVEMPPRSPV SEAEEAVSLE QLRSVRQLEA LARVHILLAL VLSPGAEGYE
  1321  DCCLAAYAFF RHIWQVSLMT AGKSVLENRP LAATSSHLLL PKKEKENERS KEKEKERSKE
  1381  KENERSKEKD KEKGKEEKVK EPKQSQSPAP IKQLEDLPMS IEEWASYSCP EEVLSVLKQD
  1441  RSDSTVNPSS IQKPTYSLYF LDHLVKALQK MCLHELTVPV LQLGVLISDS VVGSKGLSDL
  1501  YHLRLAHACS ELKLREAAAR HEEAVGQVCV SELEQASCRK EIALKKEKNK EPLLEESLPA
  1561  LNEQTLPVQP GEIKPLDAKD KILKMNGETG RDLDGTSFPH LWMLKAEVLL EMNLYQPARL
  1621  LLSEAYLAFQ ELDEPCAEAQ CLLLLAQLAN KEKNYGQAKK MIAQAQHLGG SEEFWYNSTL
  1681  TLAEALLSME HSGREATVCH IFQKLINAFK ILKKERPNRL PLLEFMITDL EARCLSLRVR
  1741  VAQHSAVTEP TECSLLLKEM DDGLLEIERK FIDCGCKENC VDVKLERAKI KRLRAQNEKD
  1801  EEQKTAYYLE AYGLAQGAVA EEEGRLHSIQ GLYGLAQGAM AEEEGRLHSV QGLLSLQDLQ
  1861  NVNTPLMRKL ARLKLGLVEM ALDMLQFIWE EAHGQQSEQG SLEKLLADYL QNTSDYTSVG
  1921  LQWFTLKRTL AHGALAQLGS LQPLSVGCVE IRARLLGLAG RALHLLAMQA DPVHPTCYWE
  1981  AGPSVGAKLS GLKSLELEVE EEGATKSSRD PPASRAAPEE HCRRGEDLKR RMVLAQQYLA
  2041  QASEVLLQCL QVALGSGLLD VAAAASLEMV ECVGTLDPAT TCQFLALSQS CSASETMRDV
  2101  LLAATANTSS SQLAALLQLQ HQLRCQDRTT TSLGARVEQR LAAVSKAWQN LCVTEQHFNL
  2161  LNEMPPTFWI LFLHLSGDRS RLYGAAYEKP KFITAAKGKV QAVGGSCKVM RLAISPTAFS
  2221  HLLACAQQFR KQTQAQVYSE DMALNIGSEP EGLQVEEKER PVQRLSSVLG PLEELLQPLF
  2281  PLLSLSKARV QTPAVVADSG KSKGKDKERK TSTGQHSTVQ PEVADKIVLV ADRHLLELPL
  2341  EGLSVFDEGT ISSVSREFSL QMLWNRLHKE ETEGGVKKEG RSRDPKKRSL AKKGRKGSIP
  2401  RTIPPDCIIV DSDNFKFVVD PYEEAQGPEM LTPVSITQDI LERFQDTFTS RWAGHLGSKH
  2461  FPSQAQWEQA LGSCSGFFFY GMESFLSHIL VERLVAMNLQ ECQVAVLLDL ARSYQSLKRH
  2521  MESVEHRRSV GRWEANWRNS ASPSEDEWRR GGEPRRGFSD LEGQAAAAPK LRAPSHHAQL
  2581  GPVWAAAPSH RVVQAWTCLP SAAGAPALAS ALGSAPLPTH PHLPAPIPSS QLALPFLGLS
  2641  PALGAASARD PPPATSRKAA AWTSSSACLC APWGLRRGWS CVSSRGQDKG GLPLAALVLS
  2701  CLDQKTIQTV SLFLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

testis: 40 nTPM
skeletal muscle: 29 nTPM
hypothalamus: 12 nTPM
fallopian tube: 11 nTPM
cerebral cortex: 9.5 nTPM
hippocampal formation: 9.2 nTPM

Single-cell type

ependymal cells: 592 nCPM
respiratory ciliated cells: 430 nCPM
endometrial ciliated cells: 290 nCPM
epididymal efferent duct ciliated cells: 262 nCPM
fallopian tube ciliated cells: 250 nCPM
choroid plexus epithelial cells: 181 nCPM

Immune cell

non-classical monocyte: 0.6 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 41 nTPM
midbrain: 29 nTPM
medulla oblongata: 23 nTPM
spinal cord: 15 nTPM
pons: 12 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

axoneme

Protein domainsUniProt · Pfam · InterPro

Cilia- and flagella-associated protein 46
CFAP46, N-terminal TPR repeat
CFAP46, N-terminal TPR repeats

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP46 as an antibody target. Whether an autoantibody or antibody against CFAP46 could matter depends on whether native CFAP46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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