CFAP276
Cilia- and flagella-associated protein 276
Also known as: C1orf194, CF276_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T5A4
- Gene
- CFAP276
- Ensembl
- ENSG00000179902
- Chromosome
- 1
- Canonical length
- 169 aa
- Protein class
- Disease related genes, Predicted intracellular proteins
- Subcellular location
- Mid piece,Principal piece,End piece
OverviewNCBI Gene
Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
169 residues, UniProt reviewed canonical sequence.
>Q5T5A4|CFAP276
1 MPPTRDPFQQ PTLDNDDSYL GELRASKKLP YKNPTHLAQQ QEPWSRLNST PTITSMRRDA
61 YYFDPEIPKD DLDFRLAALY NHHTGTFKNK SEILLNQKTT QDTYRTKIQF PGEFLTPPTP
121 PITFLANIRH WINPKKESIH SIQGSIVSPH TAATNGGYSR KKDGGFFSTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CFAP276 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 140 nTPM
Expression across tissuesHPA
Tissue
- testis: 140 nTPM
- choroid plexus: 122 nTPM
- fallopian tube: 100 nTPM
- lung: 4.3 nTPM
- basal ganglia: 2.9 nTPM
- hippocampal formation: 2.8 nTPM
Single-cell type
- late spermatids: 5,595 nCPM
- early spermatids: 2,229 nCPM
- epididymal efferent duct ciliated cells: 1,878 nCPM
- late primary spermatocytes: 1,784 nCPM
- fallopian tube ciliated cells: 1,666 nCPM
- respiratory ciliated cells: 1,020 nCPM
Immune cell
- eosinophil: 2.1 nTPM
- neutrophil: 0.3 nTPM
- MAIT T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- choroid plexus: 28 nTPM
- medulla oblongata: 5.2 nTPM
- midbrain: 4.8 nTPM
- hippocampal formation: 2.7 nTPM
- white matter: 2.7 nTPM
- hypothalamus: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.77
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cilia- and flagella-associated protein 276
- Protein of unknown function (DUF3695)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CFAP276 as an antibody target. Whether an autoantibody or antibody against CFAP276 could matter depends on whether native CFAP276 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CFAP276 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CFAP276 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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