Seroatlas · Human Serome Atlas

CFAP263

Cilia- and flagella-associated protein 263

Also known as: CCDC113, CF263_HUMAN, DKFZp434N1418, HSPC065

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0I3
Gene: CFAP263
Ensembl: ENSG00000103021
Chromosome: 16
Canonical length: 377 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in cilium assembly. Located in centriolar satellite and ciliary basal body. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q9H0I3|CFAP263
     1  MTDDESESVL SDSHEGSELE LPVIQLCGLV EELSYVNSAL KTETEMFEKY YAKLEPRDQR
    61  PPRLSEIKIS AADYAQFRGR RRSKSRTGMD RGVGLTADQK LELVQKEVAD MKDDLRHTRA
   121  NAERDLQHHE AIIEEAEIRW SEVSREVHEF EKDILKAISK KKGSILATQK VMKYIEDMNR
   181  RRDNMKEKLR LKNVSLKVQR KKMLLQLRQK EEVSEALHDV DFQQLKIENA QFLETIEARN
   241  QELTQLKLSS GNTLQVLNAY KSKLHKAMEI YLNLDKEILL RKELLEKIEK ETLQVEEDRA
   301  KAEAVNKRLR KQLAEFRAPQ VMTYVREKIL NADLEKSIRM WERKVEIAEM SLKGHRKAWN
   361  RMKITNEQLQ ADYLAGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP263 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 29 nTPM
testis: 10 nTPM
choroid plexus: 9 nTPM
retina: 8.7 nTPM
parathyroid gland: 6.4 nTPM
basal ganglia: 6.3 nTPM

Single-cell type

respiratory ciliated cells: 374 nCPM
fallopian tube ciliated cells: 335 nCPM
late spermatids: 230 nCPM
early spermatids: 222 nCPM
endometrial ciliated cells: 173 nCPM
epididymal efferent duct ciliated cells: 128 nCPM

Immune cell

basophil: 6.5 nTPM
neutrophil: 0.6 nTPM
eosinophil: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

choroid plexus: 25 nTPM
midbrain: 25 nTPM
medulla oblongata: 20 nTPM
spinal cord: 20 nTPM
amygdala: 16 nTPM
white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cilium assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP263 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP263 as an antibody target. Whether an autoantibody or antibody against CFAP263 could matter depends on whether native CFAP263 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP263 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP263 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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