Seroatlas · Human Serome Atlas

CFAP20DC

Protein CFAP20DC

Also known as: C3orf67, CF20D_HUMAN, FLJ42117, FLJ42930

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVT6
Gene: CFAP20DC
Ensembl: ENSG00000163689
Chromosome: 3
Canonical length: 689 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for CFAP20DC in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

689 residues, UniProt reviewed canonical sequence.

>Q6ZVT6|CFAP20DC
     1  MIKRKIWCNL CIDLVAFTSE IFKGAVFQSL DGIVVSANCK LRKIFTLKSK PQDTADKDAV
    61  YGVPFSTDEP TDIIPRSCQL MTDVPHVTQL LNMTKLRQTE IKFGGHPLRS AESDQFINRG
   121  TSITRNSKNQ DVCHIAFGSK VLGPPPLSGR RNNMKISSET VRSVGSKNNR SCQPSTVEKC
   181  VNGTEMSALL IPESEEQGNK ENIHQIKQTV PIHAANLHIM HPHPPQEPSA DKNNNRRRLR
   241  LKSTSRERTE TPSGSSSGNN RIEDKASTIL TTVSQQGAEL LNSGTLGPQS PDQSDEWIFP
   301  ENADHISYLA SSRQSLLLGD DSCNPSHLWL EASKESEHDQ QAEESQSVPK DIFTFSSRPR
   361  SAPHGKTQTM SPEELSFILD LKEDNSVTSR DTQSEDDFYG GDSSEEGNHS IQGSRGPTTG
   421  PSELTQLTLE SLLGKAAKRT SKEYLRSAYT EAGATESQDS SMEQIDRNNF EMSLLPTTCL
   481  SPTGRRCGSC QKTPEPVIKA KDLSAQQVPA SLNKTSLKEI SGERLSSIPE ASEYDWRNYQ
   541  PSQMSESELQ MLASLRWQQN EELEDAGTSH GLSASQVDNC NVSISTSSDD TTTWNSCLPP
   601  PVNQGRHYQK EMNPPSPSNP RDWLNMLSPP IVPPSQQPAE QRPDSCESLS VQGEEDLSVE
   661  EDEEVLTLLY DPCLNCYFDP QTGKYYELV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP20DC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
esophagus: 8.1 nTPM
tonsil: 3 nTPM
fallopian tube: 2.7 nTPM
cervix: 2.2 nTPM
vagina: 2.2 nTPM

Single-cell type

esophageal apical cells: 524 nCPM
late spermatids: 176 nCPM
early spermatids: 171 nCPM
late primary spermatocytes: 131 nCPM
respiratory ciliated cells: 126 nCPM
gonadotrophs: 111 nCPM

Immune cell

T-reg: 0.5 nTPM
memory B-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

midbrain: 2.5 nTPM
cerebral cortex: 2.2 nTPM
hippocampal formation: 2.2 nTPM
medulla oblongata: 2.1 nTPM
basal ganglia: 2 nTPM
thalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP20DC as an antibody target. Whether an autoantibody or antibody against CFAP20DC could matter depends on whether native CFAP20DC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP20DC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP20DC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...