Seroatlas · Human Serome Atlas

CFAP206

Cilia- and flagella-associated protein 206

Also known as: C6orf165, CF206_HUMAN, dJ382I10.1, FLJ25974

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYR0
Gene
CFAP206
Ensembl
ENSG00000272514
Chromosome
6
Canonical length
622 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in regulation of cilium beat frequency; regulation of flagellated sperm motility; and sperm axoneme assembly. Predicted to be located in A axonemal microtubule and motile cilium. Predicted to be part of radial spoke. Predicted to be active in axoneme and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>Q8IYR0|CFAP206
     1  MPPTQAESVI RSIIREIGQE CAAHGEIVSE TLIAFMVKAV VLDPSNGFNM DRTLMKSDVQ
    61  NLVKLCMTRL LDTKNPSLDT IKMQVYFDMN YTNRVEFLEE HHRVLESRLG SVTREITDNR
   121  ACAKEELESL YRKIISYVLL RSGLGSPTDI KTVREVTAAL QSVFPQAELG TFLTLSKKDK
   181  ERQLKELTMI VTGIRLFNRD CGKGGEGIDD LPAVLHVAIP ATMQHIDYQL ETARSQVYRY
   241  TAILEKAAND PLMRAELQPY MLKEALYNIR QYEVFLQIIL SDIITGAQEV EMMTKQLGAH
   301  LEQLKMTIKS KIAVPTSQVF PIFIALSTLW TSLQDETIVV GVLSNLFTHI QPFLGAHELY
   361  FPERVMQCHL NGATVKTDVC RMKEHMEDRV NVADFRKLEW LFPETTANFD KLLIQYRGFC
   421  AYTFAATDGL LLPGNPAIGI LKYKEKYYTF NSKDAAYSFA ENPEHYIDIV REKAKKNTEL
   481  IQLLELHQQF ETFIPYSQMR DADKHYIKPI TKCESSTQTN THILPPTIVR SYEWNEWELR
   541  RKAIKLANLR QKVTHSVQTD LSHLRRENCS QVYPPKDTST QSMREDSTGV PRPQIYLAGL
   601  RGGKSEITDE VKVNLTRDVD ET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP206 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • testis: 55 nTPM
  • fallopian tube: 21 nTPM
  • choroid plexus: 5.7 nTPM
  • hypothalamus: 1.6 nTPM
  • hippocampal formation: 1.4 nTPM
  • lung: 1.4 nTPM

Single-cell type

  • ependymal cells: 106 nCPM
  • choroid plexus epithelial cells: 29 nCPM
  • other brain neurons: 5.5 nCPM
  • brain inhibitory neurons: 4.5 nCPM
  • brain excitatory neurons: 4.4 nCPM
  • astrocytes: 2.7 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 8.9 nTPM
  • midbrain: 5.3 nTPM
  • medulla oblongata: 4.4 nTPM
  • hypothalamus: 2.9 nTPM
  • spinal cord: 2.9 nTPM
  • basal ganglia: 1.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFAP206.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 96 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
DepMap mean gene effect
-0.04
DepMap dependency class
selective

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cilia- and flagella-associated protein 206
  • Domain of unknown function

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP206 as an antibody target. Whether an autoantibody or antibody against CFAP206 could matter depends on whether native CFAP206 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP206 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP206 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFAP206. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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