Seroatlas · Human Serome Atlas

CFAP184

Cilia- and flagella-associated protein 184

Also known as: CCDC96, CF184_HUMAN, FLJ90575

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M329
Gene: CFAP184
Ensembl: ENSG00000173013
Chromosome: 4
Canonical length: 555 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cilium assembly. Predicted to be located in centrosome; cilium; and cytoplasm. Predicted to be active in axoneme and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q2M329|CFAP184
     1  MDVSSEHTKD PGGEGGDGES LAARPSKIKA SSGPPTSPEP GELESEPEEE EEEQAASQGG
    61  TAADEQAEAP KGLTAAEAAG EEGPGEPGRP AEPQPEPEEP AEVGAEEPAQ PEPGAGPEEL
   121  EAEAGAEELE QAAEGKEVRF QASLPLTRID EEEAAAAPEA ETERVEGEEE DKEETQRDGA
   181  ESKERDGEGR PAKSQEEGKR LYGRDEFEDL EWSEEVQKLQ EQQLRSDLLD QYRSLLVERN
   241  RSQRYNLYLQ HKIFEALRRK KGLEAAEVAD RGAEAEAPEK EQAYLRHLGM LEELKKQQAD
   301  DLQWYHQELG QLKRQCQEKL TRVEKEWRRF QALKKQVVMQ AMGSCRMRGG RQAALREVEQ
   361  IQALEDKKEK EMSAVRLENI QLKQSLVHFE TRMRTQEDLT QGLLLIDFEQ LKIENQTFNE
   421  KIEERNEELL KLRSKVTNSV QVITHVKEKL HFMDMENACK KTQLAEIEAQ AALGRDILTK
   481  TKQAREGLRT DNIRLNQKCG LLGKDSLLRD LEEKVDKTEL LHRRLESLKR HHASLTLSCR
   541  GVRQKIREAK AFLPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP184 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

testis: 62 nTPM
choroid plexus: 12 nTPM
fallopian tube: 10 nTPM
basal ganglia: 5.5 nTPM
hypothalamus: 4.2 nTPM
hippocampal formation: 3.7 nTPM

Single-cell type

fallopian tube ciliated cells: 0.8 nCPM
respiratory ciliated cells: 0.7 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM
endometrial ciliated cells: 0.3 nCPM
early spermatids: 0.2 nCPM
late spermatids: 0.2 nCPM

Immune cell

intermediate monocyte: 1.2 nTPM
non-classical monocyte: 1 nTPM
myeloid DC: 0.5 nTPM
naive CD8 T-cell: 0.5 nTPM
classical monocyte: 0.4 nTPM
MAIT T-cell: 0.2 nTPM

Brain region

choroid plexus: 12 nTPM
midbrain: 7 nTPM
medulla oblongata: 6.3 nTPM
spinal cord: 4.8 nTPM
hypothalamus: 4.3 nTPM
hippocampal formation: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cilium assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP184 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TFIP11

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP184 as an antibody target. Whether an autoantibody or antibody against CFAP184 could matter depends on whether native CFAP184 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP184 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP184 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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