Seroatlas · Human Serome Atlas

CFAP144

Cilia- and flagella-associated protein 144

Also known as: CF144_HUMAN, FAM183A, hCG23177, LOC440585

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NL82
Gene: CFAP144
Ensembl: ENSG00000186973
Chromosome: 1
Canonical length: 134 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece

OverviewNCBI Gene

Enables microtubule binding activity. Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>A6NL82|CFAP144
     1  MAGHPKEKVI PDEVHQNQIL RELYLKELRT QKLYTQYHVN PLRKIHTVTR KPMSWHDNLE
    61  EPADARFLNL IHHAAQGPRK KYPETQTENQ EVGWDLEPLI NPERHDRRLN HFRVCSDITL
   121  YKAKTWGLGD DHHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP144 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 110 nTPM
choroid plexus: 61 nTPM
skin: 9.1 nTPM
hippocampal formation: 7.1 nTPM
hypothalamus: 6.8 nTPM
testis: 6.6 nTPM

Single-cell type

fallopian tube ciliated cells: 1,288 nCPM
epididymal efferent duct ciliated cells: 1,049 nCPM
respiratory ciliated cells: 951 nCPM
endometrial ciliated cells: 543 nCPM
late spermatids: 299 nCPM
ependymal cells: 184 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 20 nTPM
medulla oblongata: 18 nTPM
midbrain: 15 nTPM
spinal cord: 8.8 nTPM
white matter: 4.6 nTPM
hypothalamus: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0.04
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP144 as an antibody target. Whether an autoantibody or antibody against CFAP144 could matter depends on whether native CFAP144 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP144 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP144 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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