Seroatlas · Human Serome Atlas

CFAP119

Cilia- and flagella-associated protein 119

Also known as: C16orf93, CCDC189, CF119_HUMAN, MGC104706

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1A4V9
Gene: CFAP119
Ensembl: ENSG00000196118
Chromosome: 16
Canonical length: 331 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to act upstream of or within gene expression; single fertilization; and sperm flagellum assembly. Predicted to be located in acrosomal vesicle and sperm principal piece. Predicted to be part of radial spoke. Predicted to be active in axoneme. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>A1A4V9|CFAP119
     1  MLNRKTSHFL GMRVQSELEH LSELRREAGK DRSSVHGSAA RTRASVRTQW TTAAAAKADE
    61  DPGANLFPPP LPRPRICMWK YLDVHSMHQL EKTTNAEMRE VLAELLELGC PEQSLRDAIT
   121  LDLFCHALIF CRQQGFSLEQ TSAACALLQD LHKACIATPL GNVEECYRYF TSVLFCHGVR
   181  RPPFSIDLFK EEQLLALEDY VVNTYFRHFK LYKYVFTPQV RLDLSLTYMG LQPPKLWPES
   241  ETEKEESKEM EEQAVTPQKE ELETVAPPEP EPSHIHVLRA YIKTQVNKEL EQLQGLVEER
   301  LKASEERLSS KLTALERPFQ LPPGKGKSKT K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP119 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 37 nTPM
testis: 22 nTPM
pituitary gland: 13 nTPM
fallopian tube: 9.1 nTPM
hypothalamus: 7.9 nTPM
midbrain: 7.7 nTPM

Single-cell type

late spermatids: 466 nCPM
early spermatids: 182 nCPM
late primary spermatocytes: 157 nCPM
respiratory ciliated cells: 96 nCPM
fallopian tube ciliated cells: 80 nCPM
epididymal efferent duct ciliated cells: 79 nCPM

Immune cell

plasmacytoid DC: 12 nTPM
eosinophil: 6.1 nTPM
non-classical monocyte: 3.3 nTPM
basophil: 1.9 nTPM
NK-cell: 1.9 nTPM
myeloid DC: 1.8 nTPM

Brain region

choroid plexus: 15 nTPM
pons: 8.2 nTPM
midbrain: 6.9 nTPM
medulla oblongata: 6.5 nTPM
hippocampal formation: 5 nTPM
cerebral cortex: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP119 as an antibody target. Whether an autoantibody or antibody against CFAP119 could matter depends on whether native CFAP119 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP119 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP119 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...