Seroatlas · Human Serome Atlas

CFAP100

Cilia- and flagella-associated protein 100

Also known as: CCDC37, CP100_HUMAN, FLJ40083, MIA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q494V2
Gene
CFAP100
Ensembl
ENSG00000163885
Chromosome
3
Canonical length
611 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mid piece,Principal piece

OverviewNCBI Gene

Predicted to enable dynein complex binding activity. Predicted to be involved in cilium movement and inner dynein arm assembly. Located in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>Q494V2|CFAP100
     1  MSEIPSTIVS KNMTNDKNSL ESMNISSSSS TEENPKKQAR KNEEHGPDPS ANPFHLSGDV
    61  DFFLLRDQER NKALSERQQQ KTMRVHQKMT YSSKVSAKHT SLRRQLQLED KQEDLEARAE
   121  AEHQRAFRDY TTWKLTLTKE KNVEPENMSG YIKQKRQMFL LQYALDVKRR EIQRLETLAT
   181  KEEARLERAE KSLEKDAALF DEFVRENDCS SVQAMRAAEK ETKAKIEKIL EIRDLTTQIV
   241  NIKSEISRFE DTLKHYKVYK DFLYKLSPKE WLEEQEKKHS FLKKAKEVSE ASKESSVNST
   301  PGDKGPGIKG KASSMWAKEG QGTKKPWRFL QTMRLGRSPS YLSSPQQGSQ PSESSGGDSR
   361  GSNSPIPPTQ EDTDSDGEEP QLYFTEPQQL LDVFRELEEQ NLSLIQNSQE TEKTLEELSH
   421  TLKHTQIRMD REVNQLKQWV TTMMMSITKE EDTAAELELK ARVFHFGEYK GDQQDKLLES
   481  LNCKVLDVYR HCTGTQQEAN LGTVQMLTII EHQLDELLEN LEHVPQVKIE QAERAKEKER
   541  RIRLREEKLQ MQKILQEEHL QRARARAQAE IKKKRGRTLV CRSRPPAHRI KQQSEHTLMD
   601  KEEEELLFFF T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP100 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • testis: 31 nTPM
  • fallopian tube: 26 nTPM
  • choroid plexus: 13 nTPM
  • lung: 6.2 nTPM
  • basal ganglia: 3.4 nTPM
  • hippocampal formation: 3 nTPM

Single-cell type

  • late spermatids: 1,114 nCPM
  • early spermatids: 421 nCPM
  • ependymal cells: 314 nCPM
  • respiratory ciliated cells: 280 nCPM
  • endometrial ciliated cells: 157 nCPM
  • fallopian tube ciliated cells: 143 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 64 nTPM
  • midbrain: 52 nTPM
  • medulla oblongata: 39 nTPM
  • spinal cord: 25 nTPM
  • pons: 21 nTPM
  • white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP100 as an antibody target. Whether an autoantibody or antibody against CFAP100 could matter depends on whether native CFAP100 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP100 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP100 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFAP100. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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