CETP

Protein identityUniProt · HPA

UniProt accession

P11597

Gene

CETP

Ensembl

ENSG00000087237

Chromosome

16

Canonical length

493 aa

Protein class

Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>P11597|CETP
     1  MLAATVLTLA LLGNAHACSK GTSHEAGIVC RITKPALLVL NHETAKVIQT AFQRASYPDI
    61  TGEKAMMLLG QVKYGLHNIQ ISHLSIASSQ VELVEAKSID VSIQNVSVVF KGTLKYGYTT
   121  AWWLGIDQSI DFEIDSAIDL QINTQLTCDS GRVRTDAPDC YLSFHKLLLH LQGEREPGWI
   181  KQLFTNFISF TLKLVLKGQI CKEINVISNI MADFVQTRAA SILSDGDIGV DISLTGDPVI
   241  TASYLESHHK GHFIYKNVSE DLPLPTFSPT LLGDSRMLYF WFSERVFHSL AKVAFQDGRL
   301  MLSLMGDEFK AVLETWGFNT NQEIFQEVVG GFPSQAQVTV HCLKMPKISC QNKGVVVNSS
   361  VMVKFLFPRP DQQHSVAYTF EEDIVTTVQA SYSKKKLFLS LLDFQITPKT VSNLTESSSE
   421  SVQSFLQSMI TAVGIPEVMS RLEVVFTALM NSKGVSLFDI INPEIITRDG FLLLQMDFGF
   481  PEHLLVDFLQ SLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CETP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

56 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CETP.

Disease | AllUniProt

Conditions CETP is implicated in, by any mechanism.

• Hyperalphalipoproteinemia 1 (HALP1) MIM:143470

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 382 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hyperalphalipoproteinemia 1
• Hereditary spastic paraplegia 52
• CETP-related disorder
• Cholesterol-ester transfer protein deficiency

ReferencesPubMed · IEDB

Publications for CETP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.5

gnomAD pLI

0

gnomAD missense Z

-0.53

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cholesterol homeostasis
• cholesterol metabolic process
• cholesterol transport
• high-density lipoprotein particle remodeling
• lipid homeostasis
• lipid transport
• low-density lipoprotein particle remodeling
• negative regulation of macrophage derived foam cell differentiation
• phosphatidylcholine metabolic process
• phospholipid homeostasis
• positive regulation of cholesterol transport
• positive regulation of phospholipid transport
• regulation of cholesterol efflux
• reverse cholesterol transport
• triglyceride homeostasis
• triglyceride metabolic process
• triglyceride transport
• very-low-density lipoprotein particle remodeling

Molecular functions

• cholesterol binding
• cholesterol transfer activity
• lipid binding
• phosphatidylcholine binding
• phospholipid transporter activity
• triglyceride binding

Cellular components

• extracellular exosome
• extracellular region
• extracellular space
• high-density lipoprotein particle
• vesicle

Protein domainsUniProt · Pfam · InterPro

• Lipid-binding serum glycoprotein, C-terminal
• Lipid-binding serum glycoprotein, N-terminal
• Bactericidal permeability-increasing protein, alpha/beta domain superfamily
• Lipid-binding serum glycoprotein, conserved site
• LBP / BPI / CETP family, N-terminal domain
• LBP / BPI / CETP family, C-terminal domain
• Cholesteryl ester transfer

KeywordsUniProt

• Atherosclerosis
• Cholesterol metabolism
• Disulfide bond
• Glycoprotein
• Lipid metabolism
• Lipid transport
• Secreted
• Signal
• Steroid metabolism
• Sterol metabolism
• Transport