Seroatlas · Human Serome Atlas

CES1P1

Putative inactive carboxylesterase 4

Also known as: CES1P_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKY3
Gene: CES1P1
Canonical length: 287 aa

OverviewNCBI Gene

No narrative summary is available for CES1P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q9UKY3|CES1P1
     1  MWLPALVLAT LAASAAWAGH LSSPPLVDTL HGKVLGKFVS LEGFAQPVAV FLGIPFAKPP
    61  LGPLRFTLPQ PAEPWNFVKN ATSYPPMFTQ DPKAGQLISE LFTNRKENIP LKLSEDCLYL
   121  NIYTPADLTK KNRLPVMVWI HGGGLMVGAA STYDGLALAA HENVVVVTIQ YRLGIWGFFS
   181  TGDEHSPGNW GHLDQLAALH WVQDNIASFG GNPGSVTIFG GSVGGESVSV LVLSPLAKNL
   241  FHRAISESGV ALTSVLVKKG DVKPLAEVGL RLVRLRLDTP TSLALCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CES1P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

carboxylic ester hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CES1P1 as an antibody target. Whether an autoantibody or antibody against CES1P1 could matter depends on whether native CES1P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CES1P1 is annotated as secreted, so native CES1P1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CES1P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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