Seroatlas · Human Serome Atlas

CER1

Cerberus

Also known as: CER1_HUMAN, DAND4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95813
Gene: CER1
Ensembl: ENSG00000147869
Chromosome: 9
Canonical length: 267 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>O95813|CER1
     1  MHLLLFQLLV LLPLGKTTRH QDGRQNQSSL SPVLLPRNQR ELPTGNHEEA EEKPDLFVAV
    61  PHLVATSPAG EGQRQREKML SRFGRFWKKP EREMHPSRDS DSEPFPPGTQ SLIQPIDGMK
   121  MEKSPLREEA KKFWHHFMFR KTPASQGVIL PIKSHEVHWE TCRTVPFSQT ITHEGCEKVV
   181  VQNNLCFGKC GSVHFPGAAQ HSHTSCSHCL PAKFTTMHLP LNCTELSSVI KVVMLVEECQ
   241  CKVKTEHEDG HILHAGSQDS FIPGVSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

epididymis: 1 nTPM
cerebellum: 0.4 nTPM
kidney: 0.4 nTPM
basal ganglia: 0.3 nTPM
small intestine: 0.2 nTPM
blood vessel: 0.1 nTPM

Single-cell type

adipocytes: 1 nCPM
brain inhibitory neurons: 0.9 nCPM
distal convoluted tubule cells: 0.9 nCPM
renal collecting duct intercalated cells: 0.9 nCPM
renal connecting tubule cells: 0.9 nCPM
early spermatids: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 1.2 nTPM
basal ganglia: 1 nTPM
cerebellum: 1 nTPM
medulla oblongata: 0.8 nTPM
cerebral cortex: 0.6 nTPM
spinal cord: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -1.64
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CER1 as an antibody target. Whether an autoantibody or antibody against CER1 could matter depends on whether native CER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CER1 is annotated as secreted, so native CER1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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