Seroatlas · Human Serome Atlas

CEP57L1

Centrosomal protein CEP57L1

Also known as: bA487F23.2, C6orf182, CE57L_HUMAN, MGC21731

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYX8
Gene: CEP57L1
Ensembl: ENSG00000183137
Chromosome: 6
Canonical length: 460 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in cytoplasm; microtubule; and microtubule organizing center. Predicted to be active in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>Q8IYX8|CEP57L1
     1  MDSELMHSIV GSYHKPPERV FVPSFTQNEP SQNCHPANLE VTSPKILHSP NSQALILALK
    61  TLQEKIHRLE LERTQAEDNL NILSREAAQY KKALENETNE RNLAHQELIK QKKDISIQLS
   121  SAQSRCTLLE KQLEYTKRMV LNVEREKNMI LEQQAQLQRE KEQDQMKLYA KLEKLDVLEK
   181  ECFRLTTTQK TAEDKIKHLE EKLKEEEHQR KLFQDKASEL QTGLEISKII MSSVSNLKHS
   241  KEKKKSSKKT KCIKRRPPWQ ICSKFGALPF VAEKMRQHRD PHILQKPFNV TETRCLPKPS
   301  RTTSWCKAIP PDSEKSISIC DNLSELLMAM QDELDQMSME HQELLKQMKE TESHSVCDDI
   361  ECELECLLKK MEIKGEQISK LKKHQDSVCK LQQKVQNSKM SEASGIQQED SYPKGSKNIK
   421  NSPRKCLTDT NLFQKNSSFH PIRVHNLQMK LRRDDIMWEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP57L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
parathyroid gland: 16 nTPM
thymus: 13 nTPM
choroid plexus: 11 nTPM
retina: 10 nTPM
rectum: 10 nTPM

Single-cell type

late primary spermatocytes: 97 nCPM
erythrocyte progenitors: 95 nCPM
myonuclei: 87 nCPM
early primary spermatocytes: 85 nCPM
fibro-adipogenic progenitors: 83 nCPM
megakaryocyte-erythroid progenitors: 81 nCPM

Immune cell

basophil: 16 nTPM
NK-cell: 12 nTPM
non-classical monocyte: 9.6 nTPM
T-reg: 6.9 nTPM
memory CD8 T-cell: 6.7 nTPM
eosinophil: 6.6 nTPM

Brain region

cerebellum: 35 nTPM
white matter: 29 nTPM
cerebral cortex: 29 nTPM
basal ganglia: 25 nTPM
pons: 25 nTPM
thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP57L1 as an antibody target. Whether an autoantibody or antibody against CEP57L1 could matter depends on whether native CEP57L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP57L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP57L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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