Seroatlas · Human Serome Atlas

CEP295NL

CEP295 N-terminal-like protein

Also known as: C295L_HUMAN, DDC8, KIAA1731NL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MC4
Gene: CEP295NL
Ensembl: ENSG00000178404
Chromosome: 17
Canonical length: 621 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in regulation of centriole replication. Predicted to be located in motile cilium. Predicted to be active in centriole; centrosome; and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>Q96MC4|CEP295NL
     1  MCSGWSSSVI WRHTQFAVER CGFCGSSGPG APLEPSTLGS KHLPWEAVSA GFADRNRNMD
    61  GAMWLSLCPD NEDLLWRKKH KLLQARGKGD LALQRRADAK LWKNYQLQRL AEELRRGYQE
   121  AQHLHVGGLD RLQSARLLGW GGGRARENEP DSQGPIQRRS ARPPRAKEKH RAALSEERSC
   181  REELGQQHPR HSRPRKTAAS PEKPQTTKAT GRMNSHLAPP EKRKGRPEPS TKSGGGRCAI
   241  HPRRSKGADL ERSNPLVAAV GEIGLVEEKE KGTARAGRRQ LGKGAVCFVP ALTSRSQGQS
   301  LEGKLRDLGQ LWPADSSCRR EAVSPASQCT LREKNKWQKE LELAFEELFN INRKLKKHLC
   361  LYLALKPRMD QRPGEGHAFS EMQECGAGTP RGKKMADPEM LPAGEPRSPA EEEAQQAASK
   421  TDLKTFMGKA QNQKYQGTVK PTFRNGSQTL SPEAGIFINK EDSLLYSTES GQETPKLGTL
   481  AEGSLQLHLQ DQADRVGSTA SRQRQKAEME QRRQKQLESL EQMEHPDMSL EIHYKAELEK
   541  ERREQRRARL AHLKSSSTRA QERERGSELS TTSPSGTSLA DDDRHSQMIR DQQQQILQQN
   601  RLHKQFLEEA RKCLREFQNI C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP295NL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
bone marrow: 1.9 nTPM
lymph node: 0.7 nTPM
duodenum: 0.6 nTPM
spleen: 0.4 nTPM
appendix: 0.3 nTPM

Single-cell type

late spermatids: 3.4 nCPM
early spermatids: 2 nCPM
late primary spermatocytes: 0.3 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

memory B-cell: 5.5 nTPM
naive B-cell: 4.4 nTPM
plasmacytoid DC: 1.1 nTPM
neutrophil: 0.8 nTPM
T-reg: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

white matter: 39 nTPM
cerebral cortex: 24 nTPM
thalamus: 23 nTPM
pons: 22 nTPM
medulla oblongata: 21 nTPM
hypothalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.38
DepMap mean gene effect: 0.02
DepMap dependency class: selective

OntologyGO

Biological processes

regulation of centriole replication

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP295NL as an antibody target. Whether an autoantibody or antibody against CEP295NL could matter depends on whether native CEP295NL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP295NL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP295NL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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