Seroatlas · Human Serome Atlas

CEP295

Centrosomal protein of 295 kDa

Also known as: CE295_HUMAN, KIAA1731

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0D2
Gene
CEP295
Ensembl
ENSG00000166004
Chromosome
11
Canonical length
2601 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables microtubule binding activity. Involved in several processes, including centriole replication; positive regulation of protein acetylation; and regulation of centrosome duplication. Located in cytoplasm and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2601 residues, UniProt reviewed canonical sequence.

>Q9C0D2|CEP295
     1  MKRKVVNTHK LRLSPNEEAF ILKEDYERRR KLRLLQVREQ ERDIALQIRE DIKQRRNQQF
    61  TRLAEELRAE WEESQTQKIQ NLEKLYLASL RSMGEGHRQA KENEPDLDAL AQRAAERKRK
   121  ADLRHKEALK VQKNQKEILL KQKTWHIKAR KEALLVEKER SAKITSLPPP PPTLFENIEV
   181  KRISAVKTNS STYHHLHTFV NRETDTKRPD ARLAAEEEAK RLEELQKQAA QERMERFEKA
   241  HVRGFQAMKK IHLAQNQEKL MKELKQLQQE DLARRRQTVA QMPPQLVELP YKRSEMKEDW
   301  QRELEFAFED MYNADRKVKG NLILHLEPEP LPTVTNQIQD EELDLSMEQE NLGAAEDLPV
   361  TEAEICSSET DVPLVMKTQQ IPSKVLFKKL LNKIRSQKSL WTIKSMSEDE SEMITTVSEI
   421  ESKAPTVESG TIASKERTLS SGQEQVVESD TLTIESGPLA SEDKPLSCGT NSGKEQEINE
   481  TLPITTVAQS SVLLHPQEAA ARIRMSARQK QIMEIEEQKQ KQLELLEQIE QQKLRLETDC
   541  FRAQLEEEKR KKTQPTGVGI APASCPVISD EDSHRQMIRN YQHQLLQQNR LHRQSVETAR
   601  KQLLEYQTML KGRCPSVSAP SLITDSVISV PSWKSERPTA ISEHWDQGQR LKLSPNKYQP
   661  IQPIQTSKLE QDHFQVARQN HFPQRQVETT ETLRASDILT NQALESQEHL RQFSQTETQQ
   721  RDYKLVPKDS ETLSRALSHD RQLISQDARK ISETFGATTF QSLESQQLFS ENSENISYHL
   781  TEPSSFVPLV PQHSFSSLPV KVESGKIQEP FSAMSKSTVS TSHSIISQMH DRPLLPSENI
   841  TAQQGNMKAL QEQLDLQKKV LQATQEAQEQ LLLCKQKEVE QQTGLSVFLP LVTPDSSALL
   901  PSAKADLGRI QESSPTKNNI AVSSDHHVIS QLQDKRLSLS QPILSQQNNF KFLQEQLNIQ
   961  KDSLQARREA QEVLYVHKQS ELDRRVCSEQ AEPSFPFQVA QHTFTSLPSA DTKSGKIQEQ
  1021  HSSKSEKGLV SCQSDIPISQ DGSLSFLQQF LPLHDSLKLL QEQLTKQRDT LQARHEAQVE
  1081  LLLHRQRDLG DSKSGLVSSS SSPVVVQHSV ASQASAKAEP RRIQELYLSE KENVGPSCHL
  1141  IIPTFQDKSL SFPQHSLAQQ ENLTILQEQS QIQRVILGAK EGTQEFVHTE SELEKRISSE
  1201  QTGTSSSLSQ VDESERFQEC ISIKSDSTIP LSHPKIPRCQ ERLLRVSQHM LPLQDNLEEH
  1261  QAWLDTEKEA FHFSQKTQEN TSSEQTGSSS FIPQLVQLSF TSLASAESGT ILEPLFTESE
  1321  SKIFSSHLQI PQLQDRLLRI SQLIQPQQDN LKALQEQLAT QREAIILARQ EAREELLLHQ
  1381  SEWEGRISPE QVDTSSLPLV PQHSFASLPL NESERNQEPC SINSDNIVSS GHSEIPTLPD
  1441  GLLGLSHLVL PQQDNLIALE EHLHAQTDFL PSIEKTQKEL VLSKPCKFEE KVSSEHFIQS
  1501  HHGDLQALQQ QLDTQKKAIR SIQEVQEELL LQRLSELEKR VSSEQVCSSS FVSQVPVADS
  1561  ERTQKSFPTK SNDTLPSSHR EIPRLQDRLL SLSKPILPQQ DNMTAQLDAQ REVMYSYEKP
  1621  QEELSLNKQR KLNKSESAEH TIPSLFLPKE TEHSFIPLPF AEAKPKSTCE LYSSQNEHAA
  1681  PPSNPVIPGF QDRLLSFSQS VLTQQDNLGL QKQLDLQREV LHYSQKAQEK LLVQRQTALQ
  1741  QQIQKHEETL KDFFKDSQIS KPTVENDLKT QKMGQLRDWF PNTQDLAGND QENIRHADRN
  1801  NSDDNHLASE DTSAKQSGEH LEKDLGRRSS KPPVAKVKCG LDLNQHELSA IQEVESPAIG
  1861  RTSILGKPGI YEDRDPLRVS ISREQSFFGS PLAHDPFSCL QLVGQENVCG DDYDEAVKLK
  1921  ESVVENHAVL SYAVEEEHAY LGPTVKPDDK AKTLSYEPLS SATVSTGSLL SYENTDLSLT
  1981  DPESFSEHMD DSKQESTTSK EEETNIISSI VPSTQDIYQR QNSSDVHKSL LPAVDETTCG
  2041  HTHFQQMIDK YINEANLIPE KTDLQELEHI FPNLHHQLFK PLEPHPDFDL SSSSSGISPD
  2101  NRDFYQRSDS SSESHCATGL SKSTVYFTAL RRTSMHSSLN TSPNQQPDTN LAHVGAHSFA
  2161  TENIIGGSEQ CFEQLQPEYS SQEESQHADL PSIFSIEARD SSQGMKNQNY PSEEHTEILQ
  2221  NKKKIVHFQL SIGNLSSVYS SSDEANVFDQ LNVQHSTPCG SNSSECSTKH QLESRKESMG
  2281  FEELSKRGVV TMLQSQGLIE DNKNETCRVL DINPQVEETD SRLCVRTVEM GTSIQAPYSL
  2341  TTQNEKYFEN SAETDIPKIT KKLSQLGESE LFASSGSFSL QSSIPVWETE TGHGIMEEPE
  2401  LTLISTTDTS IAEMDFANLT LEEKSENEAK CFFQVSEFLP LVSATEASDY PAVSELSIEK
  2461  PRTASTETPR RLTPVPGSLQ EAFIKRKKSF MERSHQRQKE IRNKIHVSEN SQIKTVKEKP
  2521  SISSSVSRLK GVNKVRASFP EDRKTTQALR HQRGLRLYNQ LAEVKQQKEE KTKQEAYAQN
  2581  RARAKEFHKK TLEKLRAKNT C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP295 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 16 nTPM
  • bone marrow: 15 nTPM
  • retina: 14 nTPM
  • testis: 11 nTPM
  • lymph node: 10 nTPM
  • thymus: 9.6 nTPM

Single-cell type

  • oocytes: 157 nCPM
  • early spermatids: 120 nCPM
  • erythrocyte progenitors: 85 nCPM
  • neutrophil progenitors: 81 nCPM
  • monocyte progenitors: 76 nCPM
  • lactotrophs: 74 nCPM

Immune cell

  • neutrophil: 5.1 nTPM
  • eosinophil: 3.5 nTPM
  • naive B-cell: 3.5 nTPM
  • basophil: 3.3 nTPM
  • memory B-cell: 3.2 nTPM
  • classical monocyte: 1.7 nTPM

Brain region

  • cerebellum: 37 nTPM
  • white matter: 29 nTPM
  • cerebral cortex: 27 nTPM
  • hypothalamus: 24 nTPM
  • amygdala: 23 nTPM
  • basal ganglia: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEP295.

Disease | AllUniProt

Conditions CEP295 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 467 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Seckel syndrome 11

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP295 as an antibody target. Whether an autoantibody or antibody against CEP295 could matter depends on whether native CEP295 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP295 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP295 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEP295. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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