Seroatlas · Human Serome Atlas

CEP20

Centrosomal protein 20

Also known as: C16orf63, CEP20_HUMAN, DKFZp686N1651, FLJ31153, FOPNL, FOR20, PHSECRG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NB1
Gene: CEP20
Ensembl: ENSG00000133393
Chromosome: 16
Canonical length: 174 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centriolar satellite,Centrosome,Basal body
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in cilium assembly. Located in centriolar satellite; ciliary basal body; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>Q96NB1|CEP20
     1  MATVAELKAV LKDTLEKKGV LGHLKARIRA EVFNALDDDR EPRPSLSHEN LLINELIREY
    61  LEFNKYKYTA SVLIAESGQP VVPLDRQFLI HELNAFEESK DNTIPLLYGI LAHFLRGTKD
   121  GIQNAFLKGP SLQPSDPSLG RQPSRRKPMD DHLRKEEQKS TNIEDLHVSQ AVNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 43 nTPM
thyroid gland: 30 nTPM
testis: 29 nTPM
esophagus: 26 nTPM
lymph node: 23 nTPM
adrenal gland: 18 nTPM

Single-cell type

late spermatids: 736 nCPM
early spermatids: 305 nCPM
late primary spermatocytes: 156 nCPM
esophageal apical cells: 45 nCPM
platelets: 31 nCPM
bergmann glia: 27 nCPM

Immune cell

basophil: 38 nTPM
NK-cell: 19 nTPM
plasmacytoid DC: 18 nTPM
MAIT T-cell: 17 nTPM
T-reg: 17 nTPM
myeloid DC: 16 nTPM

Brain region

hypothalamus: 13 nTPM
choroid plexus: 12 nTPM
spinal cord: 10 nTPM
medulla oblongata: 10 nTPM
white matter: 9.9 nTPM
midbrain: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP20 as an antibody target. Whether an autoantibody or antibody against CEP20 could matter depends on whether native CEP20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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