Seroatlas · Human Serome Atlas

CEP128

Centrosomal protein of 128 kDa

Also known as: C14orf145, C14orf61, CE128_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZU80
Gene: CEP128
Ensembl: ENSG00000100629
Chromosome: 14
Canonical length: 1094 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Involved in protein localization. Located in Golgi apparatus; microtubule cytoskeleton; and nuclear membrane. Part of centriolar subdistal appendage. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1094 residues, UniProt reviewed canonical sequence.

>Q6ZU80|CEP128
     1  MAESSSESDH FRCRDRLSPW AARSTHRGTR SLPTVEVTEK VNTITSTLQD TSRNLRQVDQ
    61  MLGRYREYSN GQAGAIEHLK ESLEQSIDQL RSQRLLRNSG GRSISVTSLS ASDLDGGTGS
   121  ELHHFPPTSP LKDYGDPQGI KRMRSRTGVR FVQETDDMTQ LHGFHQSLRD LSSEQIRLGD
   181  DFNRELSRRS RSDAETKRAL EELTEKLNEA QKQEVVSDRV ERRLQELERE MRTERELVER
   241  RQDQLGLMSL QLQEALKKQE AKADEHEGAI KNKLRQTETE KNQLEQELEL SRRLLNQSEG
   301  SRETLLHQVE ELRTQLTKAE GDRKGLQHQV SQISKQQSNY QDEQGEDWRF RRGVEREKQD
   361  LEKQMSDLRV QLNFSAMASE LEEVKRCMER KDKEKAHLAS QVENLTRELE NGEKQQLQML
   421  DRLKEIQNHF DTCEAERKHA DLQISELTRH AEDATKQAER YLSELQQSEA LKEEAEKRRE
   481  DLKLKAQESI RQWKLKHKKL ERALEKQSET VDELTGKNNQ ILKEKDELKT QLYAALQQIE
   541  NLRKELNDVL TKRALQEEEL HSKEEKLRDI KSHQADLELE VKNSLDTIHR LESELKKQSK
   601  IQSQMKVEKA HLEEEIAELK KSQAQDKAKL LEMQESIKDL SAIRADLANK LAEEERAKKA
   661  VLKDLSDLTA QAKSRDEETA TIITQLKLER DVHQRELKDL TSSLQSVKTK HEQNIQELMK
   721  HFKKEKSEAE NHIRTLKAES LEEKNMAKIH RGQLEKLKSQ CDRLTEELTQ NENENKKLKL
   781  KYQCLKDQLE EREKHISIEE EHLRRMEEAR LQLKDQLLCL ETEQESILGV IGKEIDAACK
   841  TFSKDSVEKL KVFSSGPDIH YDPHRWLAES KTKLQWLCEE LKERENREKN LRHQLMLCRQ
   901  QLRNLTENKE SELQCLFQQI ERQEQLLDEI HREKRDLLEE TQRKDEEMGS LQDRVIALET
   961  STQVALDHLE SVPEKLSLLE DFKDFRDSCS SSERTDGRYS KYRVRRNSLQ HHQDDTKYRT
  1021  KSFKGDRTFL EGSHTRGLDH SSSWQDHSRF LSSPRFSYVN SFTKRTVAPD SASNKEDATM
  1081  NGTSSQPKKE EYGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP128 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

thymus: 23 nTPM
bone marrow: 5.8 nTPM
testis: 4.8 nTPM
tonsil: 4.8 nTPM
lymph node: 4.4 nTPM
breast: 3.6 nTPM

Single-cell type

plasma cells: 461 nCPM
myonuclei: 420 nCPM
monocyte progenitors: 314 nCPM
neutrophil progenitors: 245 nCPM
respiratory ciliated cells: 223 nCPM
ependymal cells: 209 nCPM

Immune cell

T-reg: 7.9 nTPM
plasmacytoid DC: 6.9 nTPM
memory CD4 T-cell: 2.4 nTPM
gdT-cell: 2.2 nTPM
myeloid DC: 2 nTPM
naive CD4 T-cell: 2 nTPM

Brain region

cerebellum: 15 nTPM
white matter: 13 nTPM
basal ganglia: 12 nTPM
medulla oblongata: 11 nTPM
pons: 10 nTPM
spinal cord: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centrosomal protein 128

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP128 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ODF2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP128 as an antibody target. Whether an autoantibody or antibody against CEP128 could matter depends on whether native CEP128 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP128 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP128 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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