Seroatlas · Human Serome Atlas

CENPVL3

Centromere protein V-like protein 3

Also known as: CENL3_HUMAN, CENPVP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0U1RRI6
Gene
CENPVL3
Ensembl
ENSG00000224109
Chromosome
X
Canonical length
272 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>A0A0U1RRI6|CENPVL3
     1  MGRVRNRATA QRRRRKRPGD PPAACAAIAV MGASRAQCPR VQVGVGSHAA AKRWLGKLRR
    61  KRRWRRAREA GSRDPLPSAP LPDPPAPAES PKELDLGAQR ERWETFRKLW GLSCEGAAKV
   121  LLDTFEYPGL VHHTGGCHCG AVRFAVWAPA DLRVVDCSCR LCRKKQHRHF LVPASRFTLL
   181  QGAESIVTYR SNTHPALHSF CSRCGVQSFH AAVSDPRVYG VAPHCLDEGT VRSVVIEEVG
   241  GGDPGEEAAE EHKAIHKTSS QSAPACPREQ EQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPVL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
5 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 5 nTPM
  • basal ganglia: 4.4 nTPM
  • testis: 3.5 nTPM
  • amygdala: 1.5 nTPM
  • cerebral cortex: 1.4 nTPM
  • hippocampal formation: 1.1 nTPM

Single-cell type

  • sertoli cells: 9.5 nCPM
  • other brain neurons: 7.6 nCPM
  • megakaryocyte-erythroid progenitors: 2.6 nCPM
  • brain inhibitory neurons: 2.3 nCPM
  • undifferentiated spermatogonia: 1.9 nCPM
  • granulosa cells: 1.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 7.9 nTPM
  • basal ganglia: 4.5 nTPM
  • midbrain: 4.5 nTPM
  • pons: 3.3 nTPM
  • cerebral cortex: 2.7 nTPM
  • thalamus: 2.5 nTPM

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPVL3 as an antibody target. Whether an autoantibody or antibody against CENPVL3 could matter depends on whether native CENPVL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPVL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPVL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CENPVL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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