Seroatlas · Human Serome Atlas

CENPV

Centromere protein V

Also known as: CENP-V, CENPV_HUMAN, p30, PRR6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7K6
Gene: CENPV
Ensembl: ENSG00000166582
Chromosome: 17
Canonical length: 275 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody,Cytosol

OverviewNCBI Gene

Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. Involved in several processes, including centromere complex assembly; pericentric heterochromatin formation; and positive regulation of cytokinesis. Acts upstream of or within ameboidal-type cell migration. Located in several cellular components, including midbody; nucleus; and spindle midzone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q7Z7K6|CENPV
     1  MRRSRSSAAA KLRGQKRSGA SGASAAPAAS AAAALAPSAT RTRRSASQAG SKSQAVEKPP
    61  SEKPRLRRSS PRAQEEGPGE PPPPELALLP PPPPPPPTPA TPTSSASNLD LGEQRERWET
   121  FQKRQKLTSE GAAKLLLDTF EYQGLVKHTG GCHCGAVRFE VWASADLHIF DCNCSICKKK
   181  QNRHFIVPAS RFKLLKGAEH ITTYTFNTHK AQHTFCKRCG VQSFYTPRSN PGGFGIAPHC
   241  LDEGTVRSMV TEEFNGSDWE KAMKEHKTIK NMSKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPV can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 20 nTPM
thymus: 16 nTPM
basal ganglia: 15 nTPM
amygdala: 15 nTPM
cerebral cortex: 13 nTPM
stomach: 13 nTPM

Single-cell type

gastric progenitor cells: 133 nCPM
early primary spermatocytes: 130 nCPM
differentiating spermatogonia: 124 nCPM
enteric transient amplifying cells: 99 nCPM
enteric stem cells: 96 nCPM
enterocytes: 93 nCPM

Immune cell

memory B-cell: 1.5 nTPM
eosinophil: 1.3 nTPM
naive CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
myeloid DC: 0.2 nTPM

Brain region

hypothalamus: 20 nTPM
medulla oblongata: 17 nTPM
cerebral cortex: 17 nTPM
white matter: 17 nTPM
amygdala: 17 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.33
gnomAD missense Z: 1.44
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPV as an antibody target. Whether an autoantibody or antibody against CENPV could matter depends on whether native CENPV is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPV is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPV as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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