Seroatlas · Human Serome Atlas

CEND1

Cell cycle exit and neuronal differentiation protein 1

Also known as: BM88, CEND_HUMAN, FLJ90066

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N111
Gene
CEND1
Ensembl
ENSG00000184524
Chromosome
11
Canonical length
149 aa
Protein class
Predicted membrane proteins
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q8N111|CEND1
     1  MESRGKSASS PKPDTKVPQV TTEAKVPPAA DGKAPLTKPS KKEAPAEKQQ PPAAPTTAPA
    61  KKTSAKADPA LLNNHSNLKP APTVPSSPDA TPEPKGPGDG AEEDEAASGG PGGRGPWSCE
   121  NFNPLLVAGG VAVAAIALIL GVAFLVRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
278 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 278 nTPM
  • cerebellum: 224 nTPM
  • hippocampal formation: 168 nTPM
  • basal ganglia: 167 nTPM
  • amygdala: 147 nTPM
  • midbrain: 140 nTPM

Single-cell type

  • brain excitatory neurons: 70 nCPM
  • other brain neurons: 58 nCPM
  • brain inhibitory neurons: 53 nCPM
  • retinal amacrine cells: 52 nCPM
  • retinal bipolar cells: 51 nCPM
  • retinal horizontal cells: 42 nCPM

Immune cell

  • memory B-cell: 0.8 nTPM
  • T-reg: 0.6 nTPM
  • gdT-cell: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 541 nTPM
  • white matter: 296 nTPM
  • thalamus: 282 nTPM
  • pons: 276 nTPM
  • medulla oblongata: 242 nTPM
  • hypothalamus: 228 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEND1.

Disease | ImmuneIEDB

Conditions an epitope on CEND1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0.6
gnomAD missense Z
-0.19
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cell cycle exit/neuronal differentiation protein 1
  • Cell cycle exit and neuronal differentiation protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEND1 as an antibody target. Whether an autoantibody or antibody against CEND1 could matter depends on whether native CEND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEND1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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