Seroatlas · Human Serome Atlas

CEMP1

Cementoblastoma-derived protein 1

Also known as: CEMP1_HUMAN, CP-23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PRD7
Gene: CEMP1
Ensembl: ENSG00000205923
Chromosome: 16
Canonical length: 247 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables hydroxyapatite binding activity. Involved in several processes, including biomineral tissue development; cell population proliferation; and odontogenesis. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q6PRD7|CEMP1
     1  MGTSSTDSQQ AGHRRCSTSN TSAENLTCLS LPGSPGKTAP LPGPAQAGAG QPLPKGCAAV
    61  KAEVGIPAPH TSQEVRIHIR RLLSWAAPGA CGLRSTPCAL PQALPQARPC PGRWFFPGCS
   121  LPTGGAQTIL SLWTWRHFLN WALQQREENS GRARRVPPVP RTAPVSKGEG SHPPQNSNGE
   181  KVKTITPDVG LHQSLTSDPT VAVLRAKRAP EAHPPRSCSG SLTARVCHMG VCQGQGDTED
   241  GRMTLMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 20 nTPM
kidney: 19 nTPM
hippocampal formation: 18 nTPM
amygdala: 18 nTPM
basal ganglia: 13 nTPM
midbrain: 13 nTPM

Single-cell type

epicardial cells: 21 nCPM
late spermatids: 14 nCPM
cardiomyocytes: 9.1 nCPM
early spermatids: 4.1 nCPM
macrophages: 3.9 nCPM
adipocytes: 1 nCPM

Immune cell

basophil: 1.9 nTPM
naive CD8 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 3.4 nTPM
medulla oblongata: 2.1 nTPM
hippocampal formation: 1.8 nTPM
amygdala: 1.6 nTPM
pons: 1.4 nTPM
spinal cord: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.21
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hydroxyapatite binding

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEMP1 as an antibody target. Whether an autoantibody or antibody against CEMP1 could matter depends on whether native CEMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEMP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...