Seroatlas · Human Serome Atlas

CELA3A

Chymotrypsin-like elastase family member 3A

Also known as: CEL3A_HUMAN, ELA3, ELA3A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09093
Gene: CELA3A
Ensembl: ENSG00000142789
Chromosome: 1
Canonical length: 270 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>P09093|CELA3A
     1  MMLRLLSSLL LVAVASGYGP PSSHSSSRVV HGEDAVPYSW PWQVSLQYEK SGSFYHTCGG
    61  SLIAPDWVVT AGHCISRDLT YQVVLGEYNL AVKEGPEQVI PINSEELFVH PLWNRSCVAC
   121  GNDIALIKLS RSAQLGDAVQ LASLPPAGDI LPNKTPCYIT GWGRLYTNGP LPDKLQQARL
   181  PVVDYKHCSR WNWWGSTVKK TMVCAGGYIR SGCNGDSGGP LNCPTEDGGW QVHGVTSFVS
   241  AFGCNFIWKP TVFTRVSAFI DWIEETIASH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CELA3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 247,620 nTPM

Expression across tissuesHPA

Tissue

pancreas: 247,620 nTPM
ovary: 48 nTPM
stomach: 43 nTPM
heart muscle: 42 nTPM
salivary gland: 42 nTPM
duodenum: 20 nTPM

Single-cell type

pancreatic acinar cells: 13,937 nCPM
pancreatic duct cells: 79 nCPM
monocytes: 15 nCPM
late spermatids: 8.3 nCPM
gastric chief cells: 7.6 nCPM
oocytes: 4.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.79
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CELA3A as an antibody target. Whether an autoantibody or antibody against CELA3A could matter depends on whether native CELA3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CELA3A is annotated as secreted, so native CELA3A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CELA3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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