CELA2B
Chymotrypsin-like elastase family member 2B
Also known as: CEL2B_HUMAN, ELA2B, RP11-265F14.2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P08218
- Gene
- CELA2B
- Ensembl
- ENSG00000215704
- Chromosome
- 1
- Canonical length
- 269 aa
- Protein class
- Enzymes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
269 residues, UniProt reviewed canonical sequence.
>P08218|CELA2B
1 MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS NGQWYHTCGG
61 SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV SVSKIVVHKD WNSDQVSKGN
121 DIALLKLANP VSLTDKIQLA CLPPAGTILP NNYPCYVTGW GRLQTNGALP DDLKQGQLLV
181 VDYATCSSSG WWGSTVKTNM ICAGGDGVIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV
241 LGCNYYYKPS IFTRVSNYND WINSVIANNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CELA2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 19,273 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 19,273 nTPM
- ovary: 4.9 nTPM
- heart muscle: 4.2 nTPM
- duodenum: 3.5 nTPM
- salivary gland: 3.2 nTPM
- adrenal gland: 2.8 nTPM
Single-cell type
- pancreatic acinar cells: 2,209 nCPM
- epicardial cells: 98 nCPM
- pancreatic duct cells: 14 nCPM
- müller glia: 11 nCPM
- vascular smooth muscle cells: 9 nCPM
- cardiomyocytes: 8.1 nCPM
Immune cell
- basophil: 0.9 nTPM
- neutrophil: 0.4 nTPM
- gdT-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 14 nTPM
- cerebellum: 11 nTPM
- thalamus: 7.7 nTPM
- white matter: 7.6 nTPM
- medulla oblongata: 6.4 nTPM
- hippocampal formation: 6.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.11
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.43
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CELA2B as an antibody target. Whether an autoantibody or antibody against CELA2B could matter depends on whether native CELA2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CELA2B is annotated as secreted, so native CELA2B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CELA2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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