Seroatlas · Human Serome Atlas

CELA1

Chymotrypsin-like elastase family member 1

Also known as: CELA1_HUMAN, ELA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNI1
Gene: CELA1
Ensembl: ENSG00000139610
Chromosome: 12
Canonical length: 258 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>Q9UNI1|CELA1
     1  MLVLYGHSTQ DLPETNARVV GGTEAGRNSW PSQISLQYRS GGSRYHTCGG TLIRQNWVMT
    61  AAHCVDYQKT FRVVAGDHNL SQNDGTEQYV SVQKIVVHPY WNSDNVAAGY DIALLRLAQS
   121  VTLNSYVQLG VLPQEGAILA NNSPCYITGW GKTKTNGQLA QTLQQAYLPS VDYAICSSSS
   181  YWGSTVKNTM VCAGGDGVRS GCQGDSGGPL HCLVNGKYSV HGVTSFVSSR GCNVSRKPTV
   241  FTQVSAYISW INNVIASN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CELA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 6.2 nTPM

Expression across tissuesHPA

Tissue

pancreas: 6.2 nTPM
adrenal gland: 2.2 nTPM
lymph node: 0.7 nTPM
thymus: 0.5 nTPM
placenta: 0.4 nTPM
spleen: 0.3 nTPM

Single-cell type

kupffer cells: 12 nCPM
extravillous trophoblasts: 5.7 nCPM
platelets: 4.2 nCPM
undifferentiated spermatogonia: 3.2 nCPM
monocytes: 2.7 nCPM
monocyte progenitors: 2.2 nCPM

Immune cell

basophil: 13 nTPM
naive CD4 T-cell: 12 nTPM
naive CD8 T-cell: 5.9 nTPM
memory CD4 T-cell: 2.7 nTPM
classical monocyte: 1.6 nTPM
total PBMC: 1.2 nTPM

Brain region

cerebral cortex: 0.5 nTPM
hippocampal formation: 0.2 nTPM
pons: 0.2 nTPM
thalamus: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CELA1 as an antibody target. Whether an autoantibody or antibody against CELA1 could matter depends on whether native CELA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CELA1 is annotated as secreted, so native CELA1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CELA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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