Seroatlas · Human Serome Atlas

CEFIP

Cardiac-enriched FHL2-interacting protein

Also known as: C10orf71, CEFIP_HUMAN, FLJ45913

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q711Q0
Gene: CEFIP
Ensembl: ENSG00000177354
Chromosome: 10
Canonical length: 1435 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade. Predicted to act upstream of or within cardiac muscle cell contraction; cardiac muscle cell differentiation; and heart morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in Z disc. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1435 residues, UniProt reviewed canonical sequence.

>Q711Q0|CEFIP
     1  MMQGNKKCTD AFSDSSSIGS VLDDADREVS SLTDRAFRSL CISEDTSFHD SYLAVSPDIT
    61  RQVFGTFHQR TVGHTQRKSG IWSQLPSQGT EHSGWAATFQ QLPKYVQGEE KYPKTSPPPT
   121  PVQRRLEVPV SGLRSSNKPV SKVSTLIKSF DRTESQRCES RPTASKPPAL KNPPKFAPLP
   181  ENSVNFCFDS AFLTVRRVPA EVSNTHQNSY QPGRKHGEQE SSKNPEMACH GSSSFLPAAN
   241  DTATLCESKF PSPHHKPVTG EPGRGKGTFL HSENSAFESW NAHQPKLLER KDTAGTVPES
   301  KAPKHYGDTT LLREPCPPER TVSPCQVQAS CSQEENRLAA GALSTSIPWG CRDPGAQVFA
   361  VEGKAPSSQP DSQEKPAQPP WRKPKTGKKG KESLQDTLEE KTQTNQRGPP LYTKHNPQEQ
   421  FSENNALDLP VEPNEHYDPP FNISKLLTPI IPSKHALDSA DSQPAERTPS PPGQLNGYQE
   481  KEPSECQSRD SYKSKAPSLL FNLKDVRKRV KSTYSSSPLL KVLDEKTRGK VDGKQEPVSN
   541  GVILPNGLEE SPPNELSKER PADDPTASHI NPQKDPTADP SEPSADSYLT LSTAPTIAKA
   601  PFYVNGEAAE RSSYENKEVE GELEMGPAGS SWCPDSREHR PRKHLSLRLC NRDPEPGGAT
   661  EKMKTHQLEN GLSRSVSQET EPEREAGLQN THLNQKFFPG PLSPEEEDVF YSDSQSDFMP
   721  SLKGKAKFST SSSDQSFASF DDQQKMWFTE NQREDRRKDV SAGDSQKDEK ENVMRKDELQ
   781  YCALSNGHAC LENRSQGEAL QRERESVSGG RTRKASAEEA NFRGSWIGEN KGTTFSQAKD
   841  LTPSPSSASN RHMLFTIKDN TLRATPVIKP IMLPLLRTMS LEDSLSSGHK EEELPRPEWG
   901  EDPGFCAPEN QDILGTSTPT NTRGTRVKCM ANEVMEDPGQ GSSMARMEAS QPAPKGNFPS
   961  MPLVGEGDRV KAPPDAAPGL VASNCKSGSA DSGKLAAPWH IPTIALPEGD IEDQPPPWQP
  1021  ENCWEEQTPG FKSHFLSTPR AGPPGRRLVP SERANSPNPG SPGESSACSP AASNIWEESS
  1081  QAPGGPELLP EEPNQASPWA SSSPARVTRR EDLTHALVWE GGSDPLLELS AEDLRTLSPR
  1141  GSLLDVATSP AGTSGRLELP AQLERTASKP PAVPPKTEKA LRRAKKLASK RRKTDQAQEK
  1201  HGESQEGKPC PEDLEQTQQR PLCPRERPRH NFPVVRSLPP PVHRHSVSGF SEPVGRRPGG
  1261  PQSLTPLPAY PATQKVLQDP QSGEYFVFDL PLQVKIKTFY DPETGKYVKV SIPSSEGASP
  1321  EPPPPDALAA PYVLYPGFQP VPVTALMPLR CSSQLSAPTF LRQGPRASAA RARTQSVHES
  1381  GLQLDPGPHG DCTPHSAGQR PHGPPQSPGE EGVEAPGLGI ISTDDLEDFA TEGIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEFIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 263 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 263 nTPM
tongue: 77 nTPM
heart muscle: 42 nTPM
parathyroid gland: 21 nTPM
esophagus: 1.4 nTPM
pancreas: 1.2 nTPM

Single-cell type

myonuclei: 461 nCPM
thymic myoid cells: 59 nCPM
cardiomyocytes: 42 nCPM
pancreatic acinar cells: 4.8 nCPM
epicardial cells: 4.5 nCPM
renal collecting duct intercalated cells: 4.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.5 nTPM
amygdala: 0.2 nTPM
cerebellum: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM
medulla oblongata: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEFIP.

Disease | AllUniProt

Conditions CEFIP is implicated in, by any mechanism.

Cardiomyopathy, dilated, 1QQ (CMD1QQ) MIM:621251

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Z disc

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEFIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FHL2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEFIP as an antibody target. Whether an autoantibody or antibody against CEFIP could matter depends on whether native CEFIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEFIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEFIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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