Seroatlas · Human Serome Atlas

CEBPZOS

Protein CEBPZOS

Also known as: CEBOS_HUMAN, CEBPZ-AS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MTT3
Gene
CEBPZOS
Ensembl
ENSG00000218739
Chromosome
2
Canonical length
80 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

80 residues, UniProt reviewed canonical sequence.

>A8MTT3|CEBPZOS
     1  MARTLEPLAK KIFKGVLVAE LVGVFGAYFL FSKMHTSQDF RQTMSKKYPF ILEVYYKSTE
    61  KSGMYGIREL DQKTWLNSKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEBPZOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 50 nTPM
  • adrenal gland: 44 nTPM
  • amygdala: 41 nTPM
  • heart muscle: 40 nTPM
  • hippocampal formation: 39 nTPM
  • cerebral cortex: 38 nTPM

Single-cell type

  • late primary spermatocytes: 125 nCPM
  • myonuclei: 115 nCPM
  • esophageal apical cells: 113 nCPM
  • early primary spermatocytes: 112 nCPM
  • cytotrophoblasts: 106 nCPM
  • oocytes: 106 nCPM

Immune cell

  • plasmacytoid DC: 49 nTPM
  • naive CD4 T-cell: 38 nTPM
  • naive CD8 T-cell: 35 nTPM
  • memory B-cell: 34 nTPM
  • MAIT T-cell: 32 nTPM
  • basophil: 32 nTPM

Brain region

  • white matter: 43 nTPM
  • hippocampal formation: 41 nTPM
  • cerebellum: 41 nTPM
  • choroid plexus: 40 nTPM
  • cerebral cortex: 39 nTPM
  • hypothalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0.01

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein CEBPZOS

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEBPZOS as an antibody target. Whether an autoantibody or antibody against CEBPZOS could matter depends on whether native CEBPZOS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEBPZOS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEBPZOS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEBPZOS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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