Seroatlas · Human Serome Atlas

CEACAM18

Cell adhesion molecule CEACAM18

Also known as: CEA18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MTB9
Gene: CEACAM18
Ensembl: ENSG00000213822
Chromosome: 19
Canonical length: 384 aa
Protein class: Predicted intracellular proteins
Subcellular location: Midbody

OverviewNCBI Gene

No narrative summary is available for CEACAM18 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>A8MTB9|CEACAM18
     1  MDLSRPRWSL WRRVFLMASL LACGICQASG QIFITQTLGI KGYRTVVALD KVPEDVQEYS
    61  WYWGANDSAG NMIISHKPPS AQQPGPMYTG RERVNREGSL LIRPTALNDT GNYTVRVVAG
   121  NETQRATGWL EVLELGSNLG ISVNASSLVE NMDSVAADCL TNVTNITWYV NDVPTSSSDR
   181  MTISPDGKTL VILRVSRYDR TIQCMIESFP EIFQRSERIS LTVAYGPDYV LLRSNPDDFN
   241  GIVTAEIGSQ VEMECICYSF LDLKYHWIHN GSLLNFSDAK MNLSSLAWEQ MGRYRCTVEN
   301  PVTQLIMYMD VRIQAPHEDL TCCPQRFLHL RIHGDVPHHA DSAGWRLHLW SPDPCSDQPL
   361  LNQDKSGSMS VHPRPEDKTR RASR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEACAM18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

duodenum: 21 nTPM
small intestine: 12 nTPM
gallbladder: 0.5 nTPM
smooth muscle: 0.2 nTPM
stomach: 0.2 nTPM
rectum: 0.1 nTPM

Single-cell type

enterocytes: 41 nCPM
gastric progenitor cells: 6.4 nCPM
enteric transient amplifying cells: 1.8 nCPM
goblet cells: 0.9 nCPM
mucous neck cells: 0.8 nCPM
enteric stem cells: 0.7 nCPM

Immune cell

neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 0.2 nTPM
medulla oblongata: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.05

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEACAM18 as an antibody target. Whether an autoantibody or antibody against CEACAM18 could matter depends on whether native CEACAM18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEACAM18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEACAM18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...