Seroatlas · Human Serome Atlas

CDY1

Testis-specific chromodomain protein Y 1

Also known as: CDY1_HUMAN, CDY1A, CDY1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6F8
Gene
CDY1
Ensembl
ENSG00000172288
Chromosome
Y
Canonical length
540 aa
Protein class
Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q9Y6F8|CDY1
     1  MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE
    61  KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNRK LFAASKNVRR
   121  KAASILSDTK NMEIINSTIE TLAPDSPFDH KTVSGFQKLE KLDPIAADQQ DTVVFKVTEG
   181  KLLRDPLSRP GAEQTGIQNK TQIHPLMSQM SGSVTASMAT GSATRKGIVV LIDPLAANGT
   241  TDMHTSVPRV KGGQRNITDD SRDQPFIKKM HFTIRLTESA STYRDIVVKK EDGFTQIVLS
   301  TRSTEKNALN TEVIKEIVNA LNSAAADDSK LVLFSAAGSV FCCGLDFGYF VKHLRNNRNT
   361  ASLEMVDTIK NFVNTFIQFK KPIVVSVNGP AIGLGASILP LCDLVWANEK AWFQTPYTTF
   421  GQSPDGCSSI TFPKMMGKAS ANEMLIAGRK LTAREACAKG LVSQVFLTGT FTQEVMIQIK
   481  ELASYNPIVL EECKALVRCN IKLELEQANE RECEVLRKIW SSAQGIESML KYVENKIDEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
1.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDY1 as an antibody target. Whether an autoantibody or antibody against CDY1 could matter depends on whether native CDY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDY1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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