CDV3
Protein CDV3 homolog
Also known as: CDV3_HUMAN, H41
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UKY7
- Gene
- CDV3
- Ensembl
- ENSG00000091527
- Chromosome
- 3
- Canonical length
- 258 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoli,Plasma membrane,Cytosol
OverviewNCBI Gene
Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
258 residues, UniProt reviewed canonical sequence.
>Q9UKY7|CDV3
1 MAETEERSLD NFFAKRDKKK KKERSNRAAS AAGAAGSAGG SSGAAGAAGG GAGAGTRPGD
61 GGTASAGAAG PGAATKAVTK DEDEWKELEQ KEVDYSGLRV QAMQISSEKE EDDNEKRQDP
121 GDNWEEGGGG GGGMEKSSGP WNKTAPVQAP PAPVIVTETP EPAMTSGVYR PPGARLTTTR
181 KTPQGPPEIY SDTQFPSLQS TAKHVESRKD KEMEKSFEVV RHKNRGRDEV SKNQALKLQL
241 DNQYAVLENQ KSSHSQYNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CDV3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 217 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 217 nTPM
- thymus: 178 nTPM
- tonsil: 152 nTPM
- bone marrow: 148 nTPM
- lymph node: 147 nTPM
- tongue: 145 nTPM
Single-cell type
- late spermatids: 959 nCPM
- early spermatids: 394 nCPM
- plasma cells: 378 nCPM
- endometrial luminal cells: 346 nCPM
- endometrial glandular cells: 283 nCPM
- alveolar cells type 1: 278 nCPM
Immune cell
- T-reg: 24 nTPM
- eosinophil: 18 nTPM
- plasmacytoid DC: 16 nTPM
- naive CD8 T-cell: 15 nTPM
- basophil: 14 nTPM
- non-classical monocyte: 14 nTPM
Brain region
- choroid plexus: 83 nTPM
- white matter: 82 nTPM
- hypothalamus: 81 nTPM
- thalamus: 80 nTPM
- medulla oblongata: 80 nTPM
- spinal cord: 76 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.52
- gnomAD pLI
- 0.77
- gnomAD missense Z
- 0.76
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein CDV3
- Carnitine deficiency-associated protein 3
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CDV3 as an antibody target. Whether an autoantibody or antibody against CDV3 could matter depends on whether native CDV3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CDV3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CDV3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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