Seroatlas · Human Serome Atlas

CDSN

Corneodesmosin

Also known as: CDSN_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15517
Gene
CDSN
Canonical length
529 aa
Protein class
Human disease related genes, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for CDSN in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q15517|CDSN
     1  MGSSRAPWMG RVGGHGMMAL LLAGLLLPGT LAKSIGTFSD PCKDPTRITS PNDPCLTGKG
    61  DSSGFSSYSG SSSSGSSISS ARSSGGGSSG SSSGSSIAQG GSAGSFKPGT GYSQVSYSSG
   121  SGSSLQGASG SSQLGSSSSH SGNSGSHSGS SSSHSSSSSS FQFSSSSFQV GNGSALPTND
   181  NSYRGILNPS QPGQSSSSSQ TFGVSSSGQS VSSNQRPCSS DIPDSPCSGG PIVSHSGPYI
   241  PSSHSVSGGQ RPVVVVVDQH GSGAPGVVQG PPCSNGGLPG KPCPPITSVD KSYGGYEVVG
   301  GSSDSYLVPG MTYSKGKIYP VGYFTKENPV KGSPGVPSFA AGPPISEGKY FSSNPIIPSQ
   361  SAASSAIAFQ PVGTGGVQLC GGGSTGSKGP CSPSSSRVPS SSSISSSSGL PYHPCGSASQ
   421  SPCSPPGTGS FSSSSSSQSS GKIILQPCGS KSSSSGHPCM SVSSLTLTGG PDGSPHPDPS
   481  AGAKPCGSSS AGKIPCRSIR DILAQVKPLG PQLADPEVFL PQGELLNSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDSN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
664 nTPM

Expression across tissuesHPA

Tissue

  • skin: 664 nTPM
  • cervix: 7.5 nTPM
  • vagina: 5.8 nTPM
  • epididymis: 2.8 nTPM
  • skeletal muscle: 0.7 nTPM
  • salivary gland: 0.6 nTPM

Single-cell type

  • cardiomyocytes: 2.9 nCPM
  • endometrial luminal cells: 2.7 nCPM
  • epicardial cells: 2.3 nCPM
  • renal collecting duct principal cells: 1.3 nCPM
  • endometrial glandular cells: 1.2 nCPM
  • epididymal efferent duct absorptive cells: 0.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDSN.

Disease | AllUniProt

Conditions CDSN is implicated in, by any mechanism.

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 165 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.46
gnomAD missense Z
1.01
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Corneodesmosin

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDSN as an antibody target. Whether an autoantibody or antibody against CDSN could matter depends on whether native CDSN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDSN is annotated as secreted, so native CDSN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CDSN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDSN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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