CDRT4
CMT1A duplicated region transcript 4 protein
Also known as: CDRT4_HUMAN, FLJ36674
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N9R6
- Gene
- CDRT4
- Ensembl
- ENSG00000239704
- Chromosome
- 17
- Canonical length
- 152 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
No narrative summary is available for CDRT4 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
152 residues, UniProt reviewed canonical sequence.
>Q8N9R6|CDRT4
1 MDARRMKKEE GLTENTGLPR KLLEKHDPWP AYVTYTSQTV KRLIEKSKTR ELECMRALEE
61 RPWASRQNKP SSVIQPKRRK SSKSSGKAVF RDTLSESTLS MWGAYSVLAM APTMIPEPTH
121 LHADSRDCPT ENYNKIIFAR KPMMRMLPTV RYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CDRT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 31 nTPM
Expression across tissuesHPA
Tissue
- pituitary gland: 31 nTPM
- epididymis: 15 nTPM
- choroid plexus: 15 nTPM
- thyroid gland: 13 nTPM
- prostate: 12 nTPM
- testis: 12 nTPM
Single-cell type
- late spermatids: 197 nCPM
- choroid plexus epithelial cells: 133 nCPM
- ependymal cells: 111 nCPM
- oligodendrocyte progenitor cells: 75 nCPM
- other brain neurons: 63 nCPM
- brain inhibitory neurons: 61 nCPM
Immune cell
- basophil: 0.8 nTPM
- T-reg: 0.3 nTPM
- NK-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- hypothalamus: 13 nTPM
- cerebellum: 11 nTPM
- medulla oblongata: 11 nTPM
- basal ganglia: 11 nTPM
- midbrain: 10 nTPM
- cerebral cortex: 10 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.88
- gnomAD pLI
- 0.1
- gnomAD missense Z
- 0.04
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- CMT1A duplicated region transcript 4 protein
- CMT1A duplicated region transcript 4 protein
InteractionsUniProt · HPA
Protein binding partners of CDRT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CDRT4 as an antibody target. Whether an autoantibody or antibody against CDRT4 could matter depends on whether native CDRT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CDRT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CDRT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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