Seroatlas · Human Serome Atlas

CDRT15L2

CMT1A duplicated region transcript 15 protein-like protein

Also known as: CD15L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MXV6
Gene
CDRT15L2
Ensembl
ENSG00000214819
Chromosome
17
Canonical length
281 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>A8MXV6|CDRT15L2
     1  MFSCCFPTSR GCCFRNGGSE SLFRQCRRRL IPHPRRLWPF VRRRTQVPQD SPGQALAGQA
    61  TPEIPSGLPL HIVLVQEEIR EPMEAQTHAP GPYADIAALA APAVEPKPAW EEPPPERALE
   121  VEGAPAKDQP SQELPEIMAP TVATGLNAGA ENVAGERSGR EGVTSTAPAS RSHAAPSPGH
   181  GGKHGGGDQG IQTGLLYLAG ERLLSFAGTT ALLLQGLFIV LILVGYISVK VMLKSIKTRL
   241  GRRVPAAPPA LRRNLLLQAW KCVCNWASRL FAPNVLPRTG S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDRT15L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • testis: 15 nTPM
  • hippocampal formation: 2.1 nTPM
  • epididymis: 0.9 nTPM
  • basal ganglia: 0.1 nTPM
  • lymph node: 0.1 nTPM
  • salivary gland: 0.1 nTPM

Single-cell type

  • late primary spermatocytes: 86 nCPM
  • early spermatids: 35 nCPM
  • late spermatids: 2.4 nCPM
  • sertoli cells: 2 nCPM
  • early primary spermatocytes: 0.6 nCPM
  • epididymal principal cells: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 3.4 nTPM
  • cerebral cortex: 1.4 nTPM
  • medulla oblongata: 0.5 nTPM
  • white matter: 0.5 nTPM
  • amygdala: 0.4 nTPM
  • basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
0.15
DepMap mean gene effect
-0.06
DepMap dependency class
selective

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDRT15L2 as an antibody target. Whether an autoantibody or antibody against CDRT15L2 could matter depends on whether native CDRT15L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDRT15L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDRT15L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDRT15L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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