Seroatlas · Human Serome Atlas

CDRT15

CMT1A duplicated region transcript 15 protein

Also known as: CDRTF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96T59
Gene: CDRT15
Ensembl: ENSG00000223510
Chromosome: 17
Canonical length: 188 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

No narrative summary is available for CDRT15 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q96T59|CDRT15
     1  MFSCCFPTSR GCCFRNGGSE SLFRRCRRRL IPHPRRLSPV VIRRIQVPQD SLGQALAGQA
    61  TPEIPLGLQL HTVLVQEIQE LIEAQTLAPG PCAEVRALPA PAAEPEPAWE EAPPERALEL
   121  EGAPAKDQTN EELPEITEVP ESIKRRLGRR VPAATPAPRG NLLLQAWMRV HSWASRLFAP
   181  NVLPGTGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDRT15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
skin: 3.1 nTPM
lymph node: 2.5 nTPM
appendix: 1.1 nTPM
spleen: 0.8 nTPM
duodenum: 0.7 nTPM

Single-cell type

late primary spermatocytes: 113 nCPM
late spermatids: 77 nCPM
early spermatids: 47 nCPM
cardiomyocytes: 1.8 nCPM
leydig cells: 0.3 nCPM
peritubular myoid cells: 0.3 nCPM

Immune cell

T-reg: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 5.7 nTPM
pons: 4.1 nTPM
medulla oblongata: 3.9 nTPM
cerebral cortex: 3.8 nTPM
hippocampal formation: 3.4 nTPM
thalamus: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -0.57
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDRT15 as an antibody target. Whether an autoantibody or antibody against CDRT15 could matter depends on whether native CDRT15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDRT15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDRT15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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