Seroatlas · Human Serome Atlas

CDR1

Cerebellar degeneration-related antigen 1

Also known as: CDR1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51861
Gene: CDR1
Canonical length: 262 aa

OverviewNCBI Gene

No narrative summary is available for CDR1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>P51861|CDR1
     1  MAWLEDVDFL EDVPLLEDIP LLEDVPLLED VPLLEDTSRL EDINLMEDMA LLEDVDLLED
    61  TDFLEDLDFS EAMDLREDKD FLEDMDSLED MALLEDVDLL EDTDFLEDPD FLEAIDLRED
   121  KDFLEDMDSL EDLEAIGRCG FSGRHGFFGR RRFSGRPKLS GRLGLLGRRG FSGRLGGYWK
   181  TWIFWKTWIF WKTWIFRKTY IGWKTWIFSG RCGLTGRPGF GGRRRFFWKT LTDWKTWISF
   241  WKTLIDWKTW ISFWKTLIDW KI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.53

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

LED repeat
WKTW repeat
WKTW repeat
LED repeat

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDR1 as an antibody target. Whether an autoantibody or antibody against CDR1 could matter depends on whether native CDR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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