Seroatlas · Human Serome Atlas

CDPF1

Cysteine-rich DPF motif domain-containing protein 1

Also known as: C22orf40, CDPF1_HUMAN, LOC150383

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NVV7
Gene
CDPF1
Ensembl
ENSG00000205643
Chromosome
22
Canonical length
123 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for CDPF1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q6NVV7|CDPF1
     1  MASHVECRPL GVFECELCTL TAPYSYVGQK PPNTQSMVLL EESYVMKDPF TSDKDRFLVL
    61  GSCCSLCSRL VCVGPECSLF YSKRFCLPCV RENINAFPQE IRQDLEKRKA PSKRTPSQPG
   121  SRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDPF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • colon: 11 nTPM
  • adrenal gland: 10 nTPM
  • spleen: 9.6 nTPM
  • prostate: 9.4 nTPM
  • cervix: 9.2 nTPM
  • heart muscle: 9.1 nTPM

Single-cell type

  • cardiomyocytes: 15 nCPM
  • cytotrophoblasts: 15 nCPM
  • migrating cytotrophoblasts: 14 nCPM
  • extravillous trophoblasts: 11 nCPM
  • ovarian stromal cells: 11 nCPM
  • hofbauer cells: 11 nCPM

Immune cell

  • naive CD4 T-cell: 11 nTPM
  • plasmacytoid DC: 11 nTPM
  • eosinophil: 11 nTPM
  • gdT-cell: 11 nTPM
  • memory CD4 T-cell: 10 nTPM
  • NK-cell: 10 nTPM

Brain region

  • medulla oblongata: 8 nTPM
  • cerebral cortex: 7.4 nTPM
  • white matter: 7.2 nTPM
  • basal ganglia: 6.9 nTPM
  • thalamus: 6.7 nTPM
  • midbrain: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Cysteine-rich DPF motif domain
  • Cysteine-rich DPF motif domain-containing protein 1
  • CDPF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDPF1 as an antibody target. Whether an autoantibody or antibody against CDPF1 could matter depends on whether native CDPF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDPF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDPF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDPF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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