Seroatlas · Human Serome Atlas

CDO1

Cysteine dioxygenase type 1

Also known as: CDO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16878
Gene: CDO1
Ensembl: ENSG00000129596
Chromosome: 5
Canonical length: 200 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables cysteine dioxygenase activity; ferrous iron binding activity; and zinc ion binding activity. Predicted to be involved in L-cysteine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q16878|CDO1
     1  MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY AKFDQYRYTR
    61  NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG NLKETLFAWP DKKSNEMVKK
   121  SERVLRENQC AYINDSIGLH RVENISHTEP AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT
   181  FHSKFGIRTP NATSGSLENN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 474 nTPM

Expression across tissuesHPA

Tissue

liver: 474 nTPM
choroid plexus: 319 nTPM
epididymis: 132 nTPM
adipose tissue: 112 nTPM
seminal vesicle: 69 nTPM
blood vessel: 60 nTPM

Single-cell type

syncytiotrophoblasts: 716 nCPM
cytotrophoblasts: 439 nCPM
migrating cytotrophoblasts: 263 nCPM
epididymal principal cells: 228 nCPM
hepatocytes: 226 nCPM
retinal pigment epithelial cells: 200 nCPM

Immune cell

memory CD4 T-cell: 1.5 nTPM
T-reg: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 200 nTPM
hypothalamus: 33 nTPM
cerebral cortex: 28 nTPM
basal ganglia: 27 nTPM
hippocampal formation: 24 nTPM
thalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.01
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

RmlC-like cupin domain superfamily
RmlC-like jelly roll fold
Cysteine dioxygenase type I
Cysteine dioxygenase type I

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDO1 as an antibody target. Whether an autoantibody or antibody against CDO1 could matter depends on whether native CDO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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