Seroatlas · Human Serome Atlas

CDNF

Cerebral dopamine neurotrophic factor

Also known as: ARMETL1, CDNF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q49AH0
Gene: CDNF
Ensembl: ENSG00000185267
Chromosome: 10
Canonical length: 187 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable growth factor activity. Predicted to be involved in dopaminergic neuron differentiation and neuron projection development. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>Q49AH0|CDNF
     1  MWCASPVAVV AFCAGLLVSH PVLTQGQEAG GRPGADCEVC KEFLNRFYKS LIDRGVNFSL
    61  DTIEKELISF CLDTKGKENR LCYYLGATKD AATKILSEVT RPMSVHMPAM KICEKLKKLD
   121  SQICELKYEK TLDLASVDLR KMRVAELKQI LHSWGEECRA CAEKTDYVNL IQELAPKYAA
   181  THPKTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDNF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 24 nTPM
tongue: 19 nTPM
testis: 9.5 nTPM
liver: 8.1 nTPM
pancreas: 5.1 nTPM
skin: 4.7 nTPM

Single-cell type

late spermatids: 476 nCPM
early spermatids: 119 nCPM
myonuclei: 63 nCPM
late primary spermatocytes: 52 nCPM
thymic myoid cells: 38 nCPM
epididymal principal cells: 33 nCPM

Immune cell

T-reg: 1.6 nTPM
naive CD4 T-cell: 1.2 nTPM
NK-cell: 0.9 nTPM
naive CD8 T-cell: 0.8 nTPM
memory CD8 T-cell: 0.5 nTPM
plasmacytoid DC: 0.4 nTPM

Brain region

white matter: 3.5 nTPM
medulla oblongata: 2.8 nTPM
midbrain: 2.7 nTPM
hypothalamus: 2.6 nTPM
spinal cord: 2.6 nTPM
choroid plexus: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

growth factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDNF as an antibody target. Whether an autoantibody or antibody against CDNF could matter depends on whether native CDNF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDNF is annotated as secreted, so native CDNF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CDNF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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