Seroatlas · Human Serome Atlas

CDKL4

Cyclin-dependent kinase-like 4

Also known as: CDKL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5MAI5
Gene: CDKL4
Ensembl: ENSG00000205111
Chromosome: 2
Canonical length: 379 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

379 residues, UniProt reviewed canonical sequence.

>Q5MAI5|CDKL4
     1  MEKYEKLAKT GEGSYGVVFK CRNKTSGQVV AVKKFVESED DPVVKKIALR EIRMLKQLKH
    61  PNLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVAD GVIKSVLWQT LQALNFCHIH
   121  NCIHRDIKPE NILITKQGII KICDFGFAQI LIPGDAYTDY VATRWYRAPE LLVGDTQYGS
   181  SVDIWAIGCV FAELLTGQPL WPGKSDVDQL YLIIRTLGKL IPRHQSIFKS NGFFHGISIP
   241  EPEDMETLEE KFSDVHPVAL NFMKGCLKMN PDDRLTCSQL LESSYFDSFQ EAQIKRKARN
   301  EGRNRRRQQQ APKSAFPRLF LKTKICQVQR NETQTSGNQI LPNGPILQNS MVTVMTNINS
   361  AVYQVTVLHL LSENFEVKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

testis: 1.8 nTPM
choroid plexus: 0.7 nTPM
pituitary gland: 0.4 nTPM
adrenal gland: 0.3 nTPM
hypothalamus: 0.2 nTPM
placenta: 0.2 nTPM

Single-cell type

endometrial glandular cells: 73 nCPM
epididymal clear cells: 55 nCPM
late primary spermatocytes: 27 nCPM
early spermatids: 26 nCPM
endometrial luminal cells: 25 nCPM
early primary spermatocytes: 20 nCPM

Immune cell

T-reg: 0.3 nTPM
memory B-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 2.5 nTPM
hypothalamus: 1.3 nTPM
basal ganglia: 0.9 nTPM
cerebral cortex: 0.8 nTPM
midbrain: 0.8 nTPM
pons: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDKL4 as an antibody target. Whether an autoantibody or antibody against CDKL4 could matter depends on whether native CDKL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDKL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDKL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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