Seroatlas · Human Serome Atlas

CDKL3

Cyclin-dependent kinase-like 3

Also known as: CDKL3_HUMAN, NKIAMRE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVW4
Gene: CDKL3
Ensembl: ENSG00000006837
Chromosome: 5
Canonical length: 592 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q8IVW4|CDKL3
     1  MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE IKFLKQFHHE
    61  NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIDYLHSNN
   121  IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDIYTDY VATRWYRAPE LVLKDTSYGK
   181  PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP
   241  QVQHPKNARK KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK
   301  AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE KKPKEIKVRV
   361  IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL VTIEPPNPIN PSTNCNGLKE
   421  NPHCGGSVTM PPINLTNSNL MAANLSSNLF HPSVRLTERA KKRRTSSQSI GQVMPNSRQE
   481  DPGPIQSQME KGIFNERTGH SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME
   541  VKQIKMLKRE SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
retina: 4 nTPM
skeletal muscle: 3 nTPM
tongue: 3 nTPM
midbrain: 2.9 nTPM
spinal cord: 2.9 nTPM

Single-cell type

late spermatids: 170 nCPM
early spermatids: 105 nCPM
podocytes: 57 nCPM
late primary spermatocytes: 54 nCPM
loop of henle epithelial cells: 47 nCPM
proximal tubule cells: 37 nCPM

Immune cell

naive CD4 T-cell: 1.4 nTPM
MAIT T-cell: 1.3 nTPM
naive CD8 T-cell: 1.1 nTPM
myeloid DC: 0.8 nTPM
memory CD8 T-cell: 0.7 nTPM
T-reg: 0.7 nTPM

Brain region

white matter: 9.4 nTPM
pons: 6.1 nTPM
spinal cord: 6 nTPM
medulla oblongata: 5.9 nTPM
cerebral cortex: 5.8 nTPM
basal ganglia: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDKL3 as an antibody target. Whether an autoantibody or antibody against CDKL3 could matter depends on whether native CDKL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDKL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDKL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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