Seroatlas · Human Serome Atlas

CDKL2

Cyclin-dependent kinase-like 2

Also known as: CDKL2_HUMAN, KKIAMRE, P56

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92772
Gene
CDKL2
Ensembl
ENSG00000138769
Chromosome
4
Canonical length
493 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome

OverviewNCBI Gene

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q92772|CDKL2
     1  MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH
    61  ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH
   121  NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG
   181  KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL
   241  PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL
   301  QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD YKLFKIKGSK
   361  IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV SVDHTRNPSV AIPPLTHNLS
   421  AVAPSINSGM GTETIPIQGY RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSGPPLSD
   481  DSGADLPQME HQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • retina: 8.9 nTPM
  • cerebral cortex: 6.4 nTPM
  • choroid plexus: 6.2 nTPM
  • cerebellum: 5.9 nTPM
  • hypothalamus: 5.8 nTPM

Single-cell type

  • late primary spermatocytes: 182 nCPM
  • alveolar cells type 2: 103 nCPM
  • choroid plexus epithelial cells: 87 nCPM
  • retinal ganglion cells: 81 nCPM
  • loop of henle epithelial cells: 73 nCPM
  • epididymal efferent duct ciliated cells: 62 nCPM

Immune cell

  • memory CD8 T-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • white matter: 17 nTPM
  • cerebral cortex: 14 nTPM
  • basal ganglia: 14 nTPM
  • pons: 14 nTPM
  • hypothalamus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDKL2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 84 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • CDKL2-related condition

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
-0.25
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDKL2 as an antibody target. Whether an autoantibody or antibody against CDKL2 could matter depends on whether native CDKL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDKL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDKL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDKL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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