Seroatlas · Human Serome Atlas

CDKL1

Cyclin-dependent kinase-like 1

Also known as: CDKL1_HUMAN, KKIALRE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00532
Gene: CDKL1
Ensembl: ENSG00000100490
Chromosome: 14
Canonical length: 357 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Flagellar centriole,Mid piece

OverviewNCBI Gene

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases that accumulates primarily in the nucleus. [provided by RefSeq, Nov 2018]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q00532|CDKL1
     1  MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKKFLESED DPVIKKIALR EIRMLKQLKH
    61  PNLVNLLEVF RRKRRLHLVF EYCDHTVLHE LDRYQRGVPE HLVKSITWQT LQAVNFCHKH
   121  NCIHRDVKPE NILITKHSVI KLCDFGFARL LTGPSDYYTD YVATRWYRSP ELLVGDTQYG
   181  PPVDVWAIGC VFAELLSGVP LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS TNQYFSGVKI
   241  PDPEDMEPLE LKFPNISYPA LGLLKGCLHM DPTQRLTCEQ LLHHPYFENI REIEDLAKEH
   301  NKPTRKTLRK SRKHHCFTET SKLQYLPQLT GSSILPALDN KKYYCDTKKL NYRFPNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

retina: 19 nTPM
kidney: 18 nTPM
endometrium: 16 nTPM
cervix: 15 nTPM
fallopian tube: 15 nTPM
adipose tissue: 13 nTPM

Single-cell type

fallopian tube ciliated cells: 299 nCPM
respiratory ciliated cells: 296 nCPM
loop of henle epithelial cells: 237 nCPM
renal collecting duct principal cells: 235 nCPM
platelets: 180 nCPM
renal collecting duct intercalated cells: 170 nCPM

Immune cell

gdT-cell: 3.5 nTPM
memory CD8 T-cell: 3.2 nTPM
MAIT T-cell: 3.1 nTPM
naive B-cell: 3.1 nTPM
basophil: 3 nTPM
eosinophil: 2.6 nTPM

Brain region

white matter: 30 nTPM
cerebral cortex: 28 nTPM
basal ganglia: 23 nTPM
choroid plexus: 22 nTPM
amygdala: 21 nTPM
spinal cord: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDKL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SIRT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDKL1 as an antibody target. Whether an autoantibody or antibody against CDKL1 could matter depends on whether native CDKL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDKL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDKL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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