Seroatlas · Human Serome Atlas

CDK5R2

Cyclin-dependent kinase 5 activator 2

Also known as: CD5R2_HUMAN, NCK5AI, P39, p39nck5ai

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13319
Gene: CDK5R2
Ensembl: ENSG00000171450
Chromosome: 2
Canonical length: 367 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q13319|CDK5R2
     1  MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPVGKGGKG ESRLKRPSVL
    61  ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN RENLLRKGRD PPDGGGTAKP
   121  LAVPVPTVPA AAATCEPPSG GSAAAQPPGS GGGKPPPPPP PAPQVAPPVP GGSPRRVIVQ
   181  ASTGELLRCL GDFVCRRCYR LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY
   241  LLCRESLRGD ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL
   301  IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASGGGPPS GGAPAASSAA RDSCAAGTKH
   361  WTMNLDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK5R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 57 nTPM
basal ganglia: 37 nTPM
hippocampal formation: 34 nTPM
pituitary gland: 33 nTPM
hypothalamus: 29 nTPM
amygdala: 26 nTPM

Single-cell type

pancreatic islet cells: 63 nCPM
retinal bipolar cells: 50 nCPM
rod photoreceptor cells: 32 nCPM
other brain neurons: 29 nCPM
neuroendocrine cells: 26 nCPM
lactotrophs: 25 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 161 nTPM
white matter: 92 nTPM
hypothalamus: 87 nTPM
basal ganglia: 86 nTPM
hippocampal formation: 86 nTPM
thalamus: 84 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.67
gnomAD missense Z: 2.17
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK5R2 as an antibody target. Whether an autoantibody or antibody against CDK5R2 could matter depends on whether native CDK5R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK5R2 is annotated at the cell surface, where native CDK5R2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDK5R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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